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- W37295079 abstract "This chapter discusses the properties of peptides, proteins, nucleic acid and virus particles. The basic properties of the solute to be purified as compared to the properties of the impurities has a decisive influence on the initial design of a purification protocol and the experimental design of the scouting and the optimization procedure. Peptides have received renewed interest, one of the reasons being the search for small protein fragments with retained biological functionality. A majority of the peptides approved for human use are produced by chemical synthesis and only a few are extracted from natural source. Peptides are composed of amino acids, being linked via a peptide bond. Proteins continue to be a very important type of biopharmaceutical. Even though smaller fragments, i.e. peptide mimetics, have been found to yield specific affinity to desired sites it is believed that tertiary structure and modifications (e.g. glycosylation) play an important role for the efficacy of biopharmaceuticals. Proteins are composed of peptide chains sometimes linked together by disulphide bonds between cysteine residues. Recombinant nucleic acids, and predominantly deoxyribonucleic acid (DNA), forms the basis for the production of recombinant proteins and peptides. DNA coding for a peptide is frequently chemically synthesized while DNA coding for larger proteins may also be purified from natural sources. Virus particles form a very inhomogeneous group of bioparticles. Virus particles contain a core of RNA or DNA, which is the essential part of the virus, being transcribed to mRNA in the infected cell leading to translation and in the end production of new virus particles with the aid of the cell machinery." @default.
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- W37295079 date "2008-01-01" @default.
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- W37295079 title "Basic Properties of Peptides, Proteins, Nucleic Acids and Virus Particles" @default.
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- W37295079 doi "https://doi.org/10.1016/b978-012374023-6.50011-7" @default.
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