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- W373376211 abstract "OBJECTIVE: Evaluate the temporal trajectory of cognitive dysfunction in relation to cytomegalovirus (CMV), herpes virus (HSV 1,2) and Toxoplasma gondii, in a well characterized representative cohort of older adults. BACKGROUND: Although Alzheimer disease and cerebrovascular injury account for a significant proportion of cognitive decline in aging there remains a number of unaccounted for contributors. While numerous associations have been reported between exposure to individual infectious agents and cognitive dysfunction, participant selection bias and cross-sectional designs preclude previous studies from exploring causal inferences. DESIGN/METHODS: In a population-based cohort aged 65+ years, cognitive function was assessed annually overfive years including the domains of attention, executive functions, memory, language, and executive functions. Antibodies to CMV, HSV 1/2 and toxoplasmosis were assayed in sera at study entry (N=1024). Exposure rates using IgG antibody levels were examined in relation to slopes of cognitive decline over time using multiple linear regressions, adjusting for potential confounders. RESULTS: Evidence of CMV exposure indexed by antibody levels was associated with lower baseline composite scores in executive, memory, language, and visuospatial domains. However, these associations were not independent of demographic variables. Exposure to CMV but not other infections agents were significantly associated with greater longitudinal decline in memory, language, and executive functions and MMSE even after adjustment for demographic factors. These associations remained after accounting for levels of non-specific inflammation, C-reactive protein (CRP). CONCLUSIONS: CMV exposure is a significant, relatively specific risk factor for cognitive deterioration in older individuals over and above the effects of age and after adjusting general markers of inflammation. This work supports further investigation into the role of significant exposures, such as chronic infections, on cognitive decline and identifies a potential target for treatment in slowing cognitive decline in specific at risk populations. Study Supported by: NIA #AG023651 Disclosure: Dr. McDade has received personal compensation for activities with UpToDate. Dr. Nimgaonkar has nothing to disclose. Dr. Yolken has nothing to disclose. Dr. Wang has nothing to disclose. Dr. McClain has nothing to disclose. Dr. Chang has nothing to disclose. Dr. Snitz has nothing to disclose. Dr. Ganguli has nothing to disclose." @default.
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- W373376211 date "2015-04-06" @default.
- W373376211 modified "2023-09-24" @default.
- W373376211 title "Increased risk for cognitive decline in aging associated with cytomegalovirus exposure in a population-based cohort (P2.174)" @default.
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