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- W37366923 endingPage "267" @default.
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- W37366923 abstract "Since their discovery, the two major breast-cancer susceptibility genes BRCA1 and BRCA2 have challenged clinicians and the basic research community to understand their biological roles, and how their loss contributes to tumorigenesis. Progress has been rapid, accelerating particularly over the last three years, and there is now a foundation of evidence on the functions of the BRCA1 and BRCA2 proteins at the cellular and molecular levels. Each protein has been associated with multiple functions (Table 1). Moreover, BRCA1 and BRCA2 show a striking degree of functional overlap, with roles for both proteins in DNA repair, cell-cycle checkpoints, control of centrosome function, and transcriptional regulation. Much work remains to be done in elucidating the molecular details of how BRCA1 and BRCA2 perform these roles, but it is clear even at this early stage that BRCA1 and BRCA2 are central to the preservation of genomic integrity in mammalian cells. This chapter will review experimental evidence for BRCA1 and BRCA2 function in DNA repair and genomic stability. Not covered here is the voluminous literature on the spectrum of BRCA1 and BRCA2 mutations associated with cancer, their population genetics, and their clinical correlates. An overview of this literature can be found in reference (13)." @default.
- W37366923 created "2016-06-24" @default.
- W37366923 creator A5059889316 @default.
- W37366923 date "2001-01-01" @default.
- W37366923 modified "2023-09-23" @default.
- W37366923 title "BRCA1 and BRCA2 in DNA Repair and Genome Stability" @default.
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