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- W37419744 abstract "Publisher Summary Neuronal cell death is a naturally occurring component of the orderly ontogeny of the nervous system. Approximately half of all neurons born ultimately die during development. Access to limiting amounts of target-derived trophic factors, the paradigmatic example of which is nerve growth factor, appears to be a major element in the regulation of this process. Unfortunately, the death of neurons is not limited to perinatal periods. Even in the adult, experimental intervention or injury that interferes with neuronal-target interactions and consequent supply of trophic support can result in neuronal loss. Neuronal death also occurs in a variety of well-described neurodegenerative disorders of which Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinsonism are notable examples. There has been speculation that such disorders may involve specific components of the trophic factor supply or response mechanism and/or that trophic factors may be useful as ameliorative agents. This chapter reviews and draws somewhat speculative conclusions about recent work on the mechanisms by which neuronal cells are maintained by trophic factors and by which they die when such support is withdrawn." @default.
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- W37419744 date "1995-01-01" @default.
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- W37419744 title "On the Mechanisms by Which Neurotrophic Factors Regulate Neuronal Survival and Cell Death" @default.
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- W37419744 doi "https://doi.org/10.1016/b978-0-08-042527-6.50010-9" @default.
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