Matches in SemOpenAlex for { <https://semopenalex.org/work/W37495426> ?p ?o ?g. }
- W37495426 endingPage "170" @default.
- W37495426 startingPage "149" @default.
- W37495426 abstract "Angiotensin II (Ang II) has been shown in several experimental conditions to stimulate the production of endothelin (ET), an endothelium-derived constricting factor. It is therefore not surprising that some of the physiological or pathological effects of angiotensin II are in fact mediated by endothelin through interaction with its specific receptors. For instance, ET receptor antagonists block part of the pressor effect of Ang II, especially when the treatment is initiated early. Accordingly, Ang II-induced vasoconstriction appears to be dependent on ET release, especially in smaller arteries. Moreover, blockade of ET receptors has a profound effect on Ang II-induced hypertrophic remodeling of small arteries. However, the contribution of ET appears to be limited to the initial phase of hypertrophy, as ET receptor antagonists do not regress already established vascular hypertrophy, but completely prevent it. Interestingly, ET also appears to mediate part of Ang II-induced vascular superoxide production in vivo. Thus, blocking ET receptors may provide similar cardiovascular benefits as inhibiting the renin-angiotensin-aldosterone system, and the combination of inhibitors of both systems therefore appears counter-intuitive. However, experimental data strongly support added benefits of a combined treatment. Therefore, the interaction between the renin-angiotensin system and ET may become clinically significant if clinical trials confirm the already available experimental data." @default.
- W37495426 created "2016-06-24" @default.
- W37495426 creator A5011395719 @default.
- W37495426 creator A5020529417 @default.
- W37495426 creator A5022716447 @default.
- W37495426 creator A5069789840 @default.
- W37495426 date "2004-01-01" @default.
- W37495426 modified "2023-10-02" @default.
- W37495426 title "Angiotensin-Endothelin Interactions" @default.
- W37495426 cites W1562905773 @default.
- W37495426 cites W1658335896 @default.
- W37495426 cites W1968421638 @default.
- W37495426 cites W1970102552 @default.
- W37495426 cites W1970323989 @default.
- W37495426 cites W1970545271 @default.
- W37495426 cites W1972313235 @default.
- W37495426 cites W1974300227 @default.
- W37495426 cites W1974974540 @default.
- W37495426 cites W1976555160 @default.
- W37495426 cites W1978345826 @default.
- W37495426 cites W1979604318 @default.
- W37495426 cites W1980762198 @default.
- W37495426 cites W1988565068 @default.
- W37495426 cites W1991869633 @default.
- W37495426 cites W1992356517 @default.
- W37495426 cites W1993023790 @default.
- W37495426 cites W1994801801 @default.
- W37495426 cites W1999812820 @default.
- W37495426 cites W2000208057 @default.
- W37495426 cites W2000756775 @default.
- W37495426 cites W2001252757 @default.
- W37495426 cites W2003269305 @default.
- W37495426 cites W2003967661 @default.
- W37495426 cites W2005876444 @default.
- W37495426 cites W2007753564 @default.
- W37495426 cites W2008024908 @default.
- W37495426 cites W2008085837 @default.
- W37495426 cites W2009143527 @default.
- W37495426 cites W2011014972 @default.
- W37495426 cites W2014578041 @default.
- W37495426 cites W2015342897 @default.
- W37495426 cites W2015896598 @default.
- W37495426 cites W2020513576 @default.
- W37495426 cites W2023578446 @default.
- W37495426 cites W2029403347 @default.
- W37495426 cites W2035102204 @default.
- W37495426 cites W2037658927 @default.
- W37495426 cites W2037867191 @default.
- W37495426 cites W2039305858 @default.
- W37495426 cites W2043666885 @default.
- W37495426 cites W2044261018 @default.
- W37495426 cites W2055877133 @default.
- W37495426 cites W2056966654 @default.
- W37495426 cites W2058362776 @default.
- W37495426 cites W2061595855 @default.
- W37495426 cites W2062790423 @default.
- W37495426 cites W2064890726 @default.
- W37495426 cites W2066741701 @default.
- W37495426 cites W2068247685 @default.
- W37495426 cites W2068399278 @default.
- W37495426 cites W2074748231 @default.
- W37495426 cites W2080422687 @default.
- W37495426 cites W2083481797 @default.
- W37495426 cites W2093705792 @default.
- W37495426 cites W2097246733 @default.
- W37495426 cites W2098974194 @default.
- W37495426 cites W2104825830 @default.
- W37495426 cites W2110182057 @default.
- W37495426 cites W2110555392 @default.
- W37495426 cites W2112936297 @default.
- W37495426 cites W2114873008 @default.
- W37495426 cites W2115779093 @default.
- W37495426 cites W2117969025 @default.
- W37495426 cites W2118092557 @default.
- W37495426 cites W2118643525 @default.
- W37495426 cites W2120687942 @default.
- W37495426 cites W2122127911 @default.
- W37495426 cites W2122216584 @default.
- W37495426 cites W2122423610 @default.
- W37495426 cites W2122520680 @default.
- W37495426 cites W2122524013 @default.
- W37495426 cites W2122886654 @default.
- W37495426 cites W2127823433 @default.
- W37495426 cites W2128019137 @default.
- W37495426 cites W2130548074 @default.
- W37495426 cites W2136378096 @default.
- W37495426 cites W2139938353 @default.
- W37495426 cites W2142961055 @default.
- W37495426 cites W2144935053 @default.
- W37495426 cites W2148663698 @default.
- W37495426 cites W2151571701 @default.
- W37495426 cites W2152097865 @default.
- W37495426 cites W2152452800 @default.
- W37495426 cites W2155902512 @default.
- W37495426 cites W2155982732 @default.
- W37495426 cites W2162804111 @default.
- W37495426 cites W2164305263 @default.
- W37495426 cites W2164487102 @default.