Matches in SemOpenAlex for { <https://semopenalex.org/work/W376024919> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W376024919 endingPage "1408" @default.
- W376024919 startingPage "1390" @default.
- W376024919 abstract "A clinical study was conducted on fleroxacin (FLRX) in 143 patients and carriers with infectious enteritis (shigellosis, Salmonella enteritis, Campylobacter enteritis, pathogenic Escherichia coli enteritis, Vibrio parahaemolyticus enteritis, cholera, multiple bacterial infections, pathogen-negative enteritis). Furthermore, its antibacterial activity against clinical isolates, fecal concentration and effect on fecal microflora were conducted. FLRX was administered orally in doses of 200 mg once a day (200 mg group) or 300 mg once a day (300 mg group) for 3 days to cholera, for 7 days to Salmonella enteritis and for 5 days to the other infectious enteritis. The clinical efficacy rates were 100% in both the 200 mg and 300 mg groups. The bacteriological efficacy rates were 100% against Shigella spp., Salmonella spp., pathogenic E. coli, V. parahaemolyticus and V. cholerae O1, and 63.6% against Campylobacter spp. in the 200 mg group. The rates of the 300 mg group were 93.3% against Shigella spp., and 100% against Campylobacter spp. and pathogenic E. coli. As adverse effects, skin rash was observed in 1 case each in both groups (1.1%, 2.1%). Abnormal laboratory findings consisted of 1 case of increased eosinophils and 1 case of elevated GOT and GPT levels in the 200 mg group (2.8%), and 1 case of elevated GPT in the 300 mg group (2.9%). The clinical usefulness rates were 92.9% and 93.3% in the 200 mg and 300 mg groups, respectively. Antibacterial activity was somewhat inferior to that fo ciprofloxacin and equal to or better than that of norfloxacin, demonstrating MIC90 values against Shigella spp., Salmonella spp., pathogenic E. coli, V. parahaemolyticus and Campylobacter spp. of 0.1, 0.2, 0.1, 0.2 and 0.78 micrograms/ml, respectively. Peak fecal concentrations of the drug were 49.0 micrograms/g and 274.4 micrograms/g in the 200 mg group, and 43.3 micrograms/g and below the detection limit (5.0 micrograms/g) in the 300 mg group. With respect to fecal microflora (4 cases), a decrease in Enterobacteriaceae was observed in 3 cases during dosing. But this change showed a tendency to recover after completion of dosing. No effects were observed on anaerobic bacteria." @default.
- W376024919 created "2016-06-24" @default.
- W376024919 creator A5006402753 @default.
- W376024919 creator A5016178887 @default.
- W376024919 creator A5033736585 @default.
- W376024919 creator A5044151774 @default.
- W376024919 creator A5047732930 @default.
- W376024919 creator A5054896178 @default.
- W376024919 creator A5075945435 @default.
- W376024919 creator A5079566765 @default.
- W376024919 creator A5083297959 @default.
- W376024919 creator A5016416932 @default.
- W376024919 date "1994-01-01" @default.
- W376024919 modified "2023-09-26" @default.
- W376024919 title "Basic and Clinical Studies of Fleroxacin on Infectious Enteritis" @default.
- W376024919 cites W1965841388 @default.
- W376024919 cites W2093350060 @default.
- W376024919 cites W2163628313 @default.
- W376024919 cites W639273921 @default.
- W376024919 doi "https://doi.org/10.11150/kansenshogakuzasshi1970.68.1390" @default.
- W376024919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7829908" @default.
- W376024919 hasPublicationYear "1994" @default.
- W376024919 type Work @default.
- W376024919 sameAs 376024919 @default.
- W376024919 citedByCount "2" @default.
- W376024919 countsByYear W3760249192014 @default.
- W376024919 crossrefType "journal-article" @default.
- W376024919 hasAuthorship W376024919A5006402753 @default.
- W376024919 hasAuthorship W376024919A5016178887 @default.
- W376024919 hasAuthorship W376024919A5016416932 @default.
- W376024919 hasAuthorship W376024919A5033736585 @default.
- W376024919 hasAuthorship W376024919A5044151774 @default.
- W376024919 hasAuthorship W376024919A5047732930 @default.
- W376024919 hasAuthorship W376024919A5054896178 @default.
- W376024919 hasAuthorship W376024919A5075945435 @default.
- W376024919 hasAuthorship W376024919A5079566765 @default.
- W376024919 hasAuthorship W376024919A5083297959 @default.
- W376024919 hasBestOaLocation W3760249191 @default.
- W376024919 hasConcept C126322002 @default.
- W376024919 hasConcept C2776575720 @default.
- W376024919 hasConcept C2776986154 @default.
- W376024919 hasConcept C2778512257 @default.
- W376024919 hasConcept C2779546430 @default.
- W376024919 hasConcept C2779802037 @default.
- W376024919 hasConcept C2779910956 @default.
- W376024919 hasConcept C2780031333 @default.
- W376024919 hasConcept C2781065037 @default.
- W376024919 hasConcept C501593827 @default.
- W376024919 hasConcept C523546767 @default.
- W376024919 hasConcept C54355233 @default.
- W376024919 hasConcept C61716771 @default.
- W376024919 hasConcept C71924100 @default.
- W376024919 hasConcept C86803240 @default.
- W376024919 hasConcept C89423630 @default.
- W376024919 hasConceptScore W376024919C126322002 @default.
- W376024919 hasConceptScore W376024919C2776575720 @default.
- W376024919 hasConceptScore W376024919C2776986154 @default.
- W376024919 hasConceptScore W376024919C2778512257 @default.
- W376024919 hasConceptScore W376024919C2779546430 @default.
- W376024919 hasConceptScore W376024919C2779802037 @default.
- W376024919 hasConceptScore W376024919C2779910956 @default.
- W376024919 hasConceptScore W376024919C2780031333 @default.
- W376024919 hasConceptScore W376024919C2781065037 @default.
- W376024919 hasConceptScore W376024919C501593827 @default.
- W376024919 hasConceptScore W376024919C523546767 @default.
- W376024919 hasConceptScore W376024919C54355233 @default.
- W376024919 hasConceptScore W376024919C61716771 @default.
- W376024919 hasConceptScore W376024919C71924100 @default.
- W376024919 hasConceptScore W376024919C86803240 @default.
- W376024919 hasConceptScore W376024919C89423630 @default.
- W376024919 hasIssue "11" @default.
- W376024919 hasLocation W3760249191 @default.
- W376024919 hasLocation W3760249192 @default.
- W376024919 hasOpenAccess W376024919 @default.
- W376024919 hasPrimaryLocation W3760249191 @default.
- W376024919 hasRelatedWork W167004257 @default.
- W376024919 hasRelatedWork W2040058879 @default.
- W376024919 hasRelatedWork W2220350082 @default.
- W376024919 hasRelatedWork W2359872088 @default.
- W376024919 hasRelatedWork W2393435485 @default.
- W376024919 hasRelatedWork W3136595976 @default.
- W376024919 hasRelatedWork W376024919 @default.
- W376024919 hasRelatedWork W4243336422 @default.
- W376024919 hasRelatedWork W4251544038 @default.
- W376024919 hasRelatedWork W2187251077 @default.
- W376024919 hasVolume "68" @default.
- W376024919 isParatext "false" @default.
- W376024919 isRetracted "false" @default.
- W376024919 magId "376024919" @default.
- W376024919 workType "article" @default.