Matches in SemOpenAlex for { <https://semopenalex.org/work/W37624189> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W37624189 endingPage "82.4" @default.
- W37624189 startingPage "82.4" @default.
- W37624189 abstract "Abstract CD4 T cells in unprimed mice can acquire CD44hi memory phenotype (MP) and the MP CD4 T cell subset become progressively more prominent with age. Although it is not clearly evident if MP CD4 T cells arise due to lymphopenia-induced proliferation or environmental antigen exposure, studies carried out in mice model suggest that naturally occurring MP CD4 T cells are hyporesponsive to both polyclonal and TCR mediated stimulus. In this report we determined that a large proportion of naturally occurring MP CD4 T cell pool in unprimed mice expressed multiple inhibitory receptor PD-1, ICOS and CTLA-4. Furthermore, inhibitory receptor expressing MP CD4 T cells become more prominent with advancing age. Our results showed that PD-1hi MP CD4 T cells isolated from aged mice were more susceptible to spontaneous apoptosis when compared with PD-1lo MP CD4 T cells. We also determined the differential expression of IFN-γ, IL-2 and IL-17 cytokines in PD-1+ versus PD-1- MP CD4 T cells isolated from unprimed young and old mice. Lastly, MP CD4 T cells purified from aged mice proliferated differentially to Con A stimulus depending on the expression of PD-1 receptor. Thus, we conclude that responses of naturally occurring MP CD4 T cells are differentially regulated by the expression of inhibitory PD-1 receptor. Supported by the funds derived from American Federation for Aging Research (AFAR)." @default.
- W37624189 created "2016-06-24" @default.
- W37624189 creator A5061224018 @default.
- W37624189 creator A5078895477 @default.
- W37624189 creator A5088596357 @default.
- W37624189 date "2009-04-01" @default.
- W37624189 modified "2023-09-25" @default.
- W37624189 title "Naturally occurring memory (CD44hi) CD4 T cell responses are differentially regulated by the expression of programmed death-1 receptor (82.4)" @default.
- W37624189 doi "https://doi.org/10.4049/jimmunol.182.supp.82.4" @default.
- W37624189 hasPublicationYear "2009" @default.
- W37624189 type Work @default.
- W37624189 sameAs 37624189 @default.
- W37624189 citedByCount "0" @default.
- W37624189 crossrefType "journal-article" @default.
- W37624189 hasAuthorship W37624189A5061224018 @default.
- W37624189 hasAuthorship W37624189A5078895477 @default.
- W37624189 hasAuthorship W37624189A5088596357 @default.
- W37624189 hasConcept C153911025 @default.
- W37624189 hasConcept C154317977 @default.
- W37624189 hasConcept C170493617 @default.
- W37624189 hasConcept C185592680 @default.
- W37624189 hasConcept C190283241 @default.
- W37624189 hasConcept C19317047 @default.
- W37624189 hasConcept C202751555 @default.
- W37624189 hasConcept C203014093 @default.
- W37624189 hasConcept C2776090121 @default.
- W37624189 hasConcept C2993002077 @default.
- W37624189 hasConcept C55493867 @default.
- W37624189 hasConcept C79484868 @default.
- W37624189 hasConcept C86803240 @default.
- W37624189 hasConcept C8891405 @default.
- W37624189 hasConceptScore W37624189C153911025 @default.
- W37624189 hasConceptScore W37624189C154317977 @default.
- W37624189 hasConceptScore W37624189C170493617 @default.
- W37624189 hasConceptScore W37624189C185592680 @default.
- W37624189 hasConceptScore W37624189C190283241 @default.
- W37624189 hasConceptScore W37624189C19317047 @default.
- W37624189 hasConceptScore W37624189C202751555 @default.
- W37624189 hasConceptScore W37624189C203014093 @default.
- W37624189 hasConceptScore W37624189C2776090121 @default.
- W37624189 hasConceptScore W37624189C2993002077 @default.
- W37624189 hasConceptScore W37624189C55493867 @default.
- W37624189 hasConceptScore W37624189C79484868 @default.
- W37624189 hasConceptScore W37624189C86803240 @default.
- W37624189 hasConceptScore W37624189C8891405 @default.
- W37624189 hasIssue "1_Supplement" @default.
- W37624189 hasLocation W376241891 @default.
- W37624189 hasOpenAccess W37624189 @default.
- W37624189 hasPrimaryLocation W376241891 @default.
- W37624189 hasRelatedWork W1968369877 @default.
- W37624189 hasRelatedWork W2033262429 @default.
- W37624189 hasRelatedWork W2068505466 @default.
- W37624189 hasRelatedWork W2098208479 @default.
- W37624189 hasRelatedWork W2106875608 @default.
- W37624189 hasRelatedWork W2134738680 @default.
- W37624189 hasRelatedWork W2141897535 @default.
- W37624189 hasRelatedWork W2793324803 @default.
- W37624189 hasRelatedWork W4288050268 @default.
- W37624189 hasRelatedWork W4313356382 @default.
- W37624189 hasVolume "182" @default.
- W37624189 isParatext "false" @default.
- W37624189 isRetracted "false" @default.
- W37624189 magId "37624189" @default.
- W37624189 workType "article" @default.