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- W37662863 abstract "Central giant cell granulomas of the jaws are classified and treated according to their biologic behaviour. The most common therapy is curettage. The aggressive type of these lesions frequently require wide resections and may damage vital structures (tooth germs, inferior alveolar nerve, etc.) resulting in fuctional and aesthetic problems. The purpose of this report is to present alternative medical treatment in aggressive GCGC of the jaws either as monotherapy or in combination with surgical treatment in order to eliminate functional problems and aesthetic defects and minimize the reccurence rate. A 15-year retrospective review of the literature emphasizing in non-surgical therapies such as calcitonin, intralesional corticosteroids, interferon-a, bisphosphonates and monoclonal antibodies. In aggressive GCGC of the jaws surgical therapy has a a high reccurence rate. Calcitonin, intralesional corticosteroids, interferon-a and bisphosphonates can be used either as monotherapy in aggressive GCGC, or when there is partial response these therapies can be combined by surgical treatment. Because of the rareness of the tumor there are no randomized clinical trials, except from calcitonin. Although surgical excision remains the treatment of choice, alternative therapies are promising but still require further investigation." @default.
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- W37662863 date "2013-05-01" @default.
- W37662863 modified "2023-09-27" @default.
- W37662863 title "PP174" @default.
- W37662863 doi "https://doi.org/10.1016/j.oraloncology.2013.03.417" @default.
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