Matches in SemOpenAlex for { <https://semopenalex.org/work/W37752657> ?p ?o ?g. }
- W37752657 abstract "Cognitive impairments, including deficits in attention processing, represent major and central elements of schizophrenic symptoms. Firstand secondgeneration antipsychotic drugs can effectively mitigate the florid symptoms of psychosis. However, treating schizophrenia’s cognitive deficits remains problematic and has met with limited success. Evidence indicates that the basal forebrain cholinergic system (BFCS) is an essential component of the neuronal circuitry involved in mediating attention processing attention processingan important aspect of cognition. The present thesis is based on the core hypothesis that cholinergic dysregulation contributes to the cognitive impairments associated with schizophrenic symptoms. Using a repeated-amphetamine (AMPH) rat model of schizophrenia, the following main hypotheses are tested: 1) Repeated, escalating AMPH administration, followed by ‘AMPHchallenges’ at previously innocuous doses, results in performance impairments on a task that measures sustained attention. 2) The consequences of repeated-AMPH administration and subsequent challenge dosing in task-performing animals include dysregulated cortical cholinergic transmission. 3) In AMPH-pretreated animals performing a sustained attention task; sub-chronic, low-dose administration of antipsychotic drugs will attenuate performance impairments. The present findings provide evidence for aberrant regulation of the basal forebrain cholinergic system and impaired sustained attention processing in a repeated-AMPH model of schizophrenia. Specifically, pretreatment with AMPH resulted in markedly attenuated performance associated cortical cholinergic" @default.
- W37752657 created "2016-06-24" @default.
- W37752657 creator A5059872030 @default.
- W37752657 date "2008-01-01" @default.
- W37752657 modified "2023-09-24" @default.
- W37752657 title "A Repeated Amphetamine Model of Impaired Attention in Schizophrenia." @default.
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