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• W37761689 startingPage "179" @default.
• W37761689 abstract "The biology of gastric carcinoma remains poorly understood and rather mysterious, often eludeing not only any rational explanation but also common sense. Thus, a decline in the incidence of gastric cancer has been reported in most countries over the last 5–6 decades; however, no satisfactory explanation for this trend has been provided; moreover, the fall in incidence concerns mainly antral carcinomas but not cancer of the cardia (whose frequency is increasing), and is more marked for the “intestinal” histologic type. Second, incidence and mortality rates show a large geographic variation, which ranges from values as low as 3 to more than 100 new cases/100000 per year; this might not be surprising, since it has been observed for many other malignancies — the characteristic of gastric cancer is that a wide variation in mortality can be detected even within small countries such as Belgium, where rather curiously the disease is much more frequent among the Flemish than the Walloon population. Third, it has been suggested that fresh fruit and vegetables exert a protective effect against the development of these tumors; however, there is evidence indicating that the disease is more frequent in rural areas, where we should reasonably expect a larger consumption of green vegetables and several fruits. Finally, recent investigations favor a pathogenetic link between Helicobacter pylori infection and gastric carcinogenesis; however, despite the interest of these observations, one should not forget that owing to the diffusion of this infection most individuals positive for Helicobacter pylori will never develop gastric cancer." @default.
• W37761689 created "2016-06-24" @default.
• W37761689 creator A5030495709 @default.
• W37761689 date "1994-01-01" @default.
• W37761689 modified "2023-09-27" @default.
• W37761689 title "Genetic Predisposition and Environmental Factors in Gastric Carcinoma" @default.
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• W37761689 doi "https://doi.org/10.1007/978-3-642-85076-9_14" @default.
• W37761689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7863095" @default.
• W37761689 hasPublicationYear "1994" @default.
• W37761689 type Work @default.

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