FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3779999> ?p ?o ?g. }

• W3779999 endingPage "47" @default.
• W3779999 startingPage "39" @default.
• W3779999 abstract "Cytokines such as tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL1β) play a role in sleep regulation in health and disease. TNFα or IL1β injection enhances non-rapid eye movement sleep. Inhibition of TNFα or IL1β reduces spontaneous sleep. Mice lacking TNFα or IL1β receptors sleep less. In normal humans and in multiple disease states, plasma levels of TNFα covary with EEG slow wave activity (SWA) and sleep propensity. Many of the symptoms induced by sleep loss, for example, sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, are elicited by injection of exogenous TNFα or IL1β. IL1β or TNFα applied unilaterally to the surface of the cortex induces state-dependent enhancement of EEG SWA ipsilaterally, suggesting greater regional sleep intensity. Interventions such as unilateral somatosensory stimulation enhance localized sleep EEG SWA, blood flow, and somatosensory cortical expression of IL1β and TNFα. State oscillations occur within cortical columns. One such state shares properties with whole animal sleep in that it is dependent on prior cellular activity, shows homeostasis, and is induced by TNFα. Extracellular ATP released during neuro- and gliotransmission enhances cytokine release via purine type 2 receptors. An ATP agonist enhances sleep, while ATP antagonists inhibit sleep. Mice lacking the P2X7 receptor have attenuated sleep rebound responses after sleep loss. TNFα and IL1β alter neuron sensitivity by changing neuromodulator/neurotransmitter receptor expression, allowing the neuron to scale its activity to the presynaptic neurons. TNFα's role in synaptic scaling is well characterized. Because the sensitivity of the postsynaptic neuron is changed, the same input will result in a different network output signal and this is a state change. The top-down paradigm of sleep regulation requires intentional action from sleep/wake regulatory brain circuits to initiate whole-organism sleep. This raises unresolved questions as to how such purposeful action might itself be initiated. In the new paradigm, sleep is initiated within networks and local sleep is a direct consequence of prior local cell activity. Whole-organism sleep is a bottom-up, self-organizing, and emergent property of the collective states of networks throughout the brain." @default.
• W3779999 created "2016-06-24" @default.
• W3779999 creator A5008039585 @default.
• W3779999 creator A5036211359 @default.
• W3779999 creator A5037968675 @default.
• W3779999 creator A5038996695 @default.
• W3779999 creator A5055649065 @default.
• W3779999 creator A5073749050 @default.
• W3779999 creator A5090674053 @default.
• W3779999 date "2011-01-01" @default.
• W3779999 modified "2023-10-16" @default.
• W3779999 title "Involvement of cytokines in slow wave sleep" @default.
• W3779999 cites W1542136448 @default.
• W3779999 cites W1806585896 @default.
• W3779999 cites W1824528611 @default.
• W3779999 cites W1965860042 @default.
• W3779999 cites W1974452299 @default.
• W3779999 cites W1975319022 @default.
• W3779999 cites W1975907857 @default.
• W3779999 cites W1977144770 @default.
• W3779999 cites W1997180428 @default.
• W3779999 cites W2002293846 @default.
• W3779999 cites W2017673011 @default.
• W3779999 cites W2018913735 @default.
• W3779999 cites W2019217443 @default.
• W3779999 cites W2020287085 @default.
• W3779999 cites W2023517019 @default.
• W3779999 cites W2025841148 @default.
• W3779999 cites W2034111532 @default.
• W3779999 cites W2047445016 @default.
• W3779999 cites W2047535883 @default.
• W3779999 cites W2048468809 @default.
• W3779999 cites W2063280673 @default.
• W3779999 cites W2072863715 @default.
• W3779999 cites W2080659194 @default.
• W3779999 cites W2083921126 @default.
• W3779999 cites W2086238474 @default.
• W3779999 cites W2086267025 @default.
• W3779999 cites W2086969201 @default.
• W3779999 cites W2090466892 @default.
• W3779999 cites W2091670988 @default.
• W3779999 cites W2096906979 @default.
• W3779999 cites W2104696695 @default.
• W3779999 cites W2111114781 @default.
• W3779999 cites W2126867943 @default.
• W3779999 cites W2127539832 @default.
• W3779999 cites W2130765148 @default.
• W3779999 cites W2164038707 @default.
• W3779999 cites W2168267944 @default.
• W3779999 cites W2173973727 @default.
• W3779999 cites W2317666265 @default.
• W3779999 cites W4292956939 @default.
• W3779999 doi "https://doi.org/10.1016/b978-0-444-53839-0.00003-x" @default.
• W3779999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3645329" @default.
• W3779999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21854954" @default.
• W3779999 hasPublicationYear "2011" @default.
• W3779999 type Work @default.
• W3779999 sameAs 3779999 @default.
• W3779999 citedByCount "103" @default.
• W3779999 countsByYear W37799992012 @default.
• W3779999 countsByYear W37799992013 @default.
• W3779999 countsByYear W37799992014 @default.
• W3779999 countsByYear W37799992015 @default.
• W3779999 countsByYear W37799992016 @default.
• W3779999 countsByYear W37799992017 @default.
• W3779999 countsByYear W37799992018 @default.
• W3779999 countsByYear W37799992019 @default.
• W3779999 countsByYear W37799992020 @default.
• W3779999 countsByYear W37799992021 @default.
• W3779999 countsByYear W37799992022 @default.
• W3779999 countsByYear W37799992023 @default.
• W3779999 crossrefType "book-chapter" @default.
• W3779999 hasAuthorship W3779999A5008039585 @default.
• W3779999 hasAuthorship W3779999A5036211359 @default.
• W3779999 hasAuthorship W3779999A5037968675 @default.
• W3779999 hasAuthorship W3779999A5038996695 @default.
• W3779999 hasAuthorship W3779999A5055649065 @default.
• W3779999 hasAuthorship W3779999A5073749050 @default.
• W3779999 hasAuthorship W3779999A5090674053 @default.
• W3779999 hasBestOaLocation W37799992 @default.
• W3779999 hasConcept C110539466 @default.
• W3779999 hasConcept C111919701 @default.
• W3779999 hasConcept C126322002 @default.
• W3779999 hasConcept C134018914 @default.
• W3779999 hasConcept C15744967 @default.
• W3779999 hasConcept C169760540 @default.
• W3779999 hasConcept C170493617 @default.
• W3779999 hasConcept C197341189 @default.
• W3779999 hasConcept C2775841894 @default.
• W3779999 hasConcept C2778938600 @default.
• W3779999 hasConcept C29993825 @default.
• W3779999 hasConcept C41008148 @default.
• W3779999 hasConcept C522805319 @default.
• W3779999 hasConcept C71924100 @default.
• W3779999 hasConceptScore W3779999C110539466 @default.
• W3779999 hasConceptScore W3779999C111919701 @default.
• W3779999 hasConceptScore W3779999C126322002 @default.
• W3779999 hasConceptScore W3779999C134018914 @default.

• next