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- W378068919 abstract "Black Africans are characterized by an increased prevalence of essential hypertension (EH). Several studies have shown that extractives from many plants are useful for the management and/or control of high blood pressure (hypertension). The aim of this study was to evaluate the antihypertensive efficacy of leaf extracts of Bryophyllum pinnatum (Lam) Oken [family: Crassulaceae], a plant commonly employed in the management of all types and grades of hypertension by some Yorubas of Western Nigeria. The effects of aqueous and methanolic leaf extracts of the herb were examined on arterial blood pressures and heart rates of normal(normotensive) and spontaneously hypertensive rats, using invasive and non-invasive techniques. Both the aqueous and methanolic leaf extracts of B. pinnatum (BP, 50-800 mg/kg i.v. or i.p.)produced dose-related, significant (P<0.05 - 0.001)decreases in arterial blood pressures and heart rates of anaesthetized normotensive and hypertensive rats. The hypotensive effects of the leaf extracts were more pronounced in the hypertensive than in normotensive rats. The leaf extracts (BP, 0.25 - 5.0 mg/ml)also produced dose-dependent, significant (P<0.05 -0.001)decreases in the rate and force of contractions of guinea-pig isolated atria, and inhibited electrical field stimulation(ES)-provoked, as well as potassium and receptor-mediated agonist drugs-induced contractions of the rat isolated thoraxic aortic strips in a non-specific manner. The inhibitory effects of the leaf extracts on the cardiovascular system of the laboratory animals used in this study were resistant to physiological doses and concentrations of standard antagonist drugs. Although further studies are in progress to elucidate the plausible mechanism/s of hypotensive action of the plant, cardiodepression and vasodilation would appear to contribute significantly to the antihypertensive effect of the herb. Nevertheless, the results obtained in this experimental animal study indicate that Bryophyllum pinnatum possesses hypotensive activity, and thus lend credence to the folkloric use of the herb in the management of hypertension by some Yoruba people of Western Nigeria." @default.
- W378068919 created "2016-06-24" @default.
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- W378068919 date "2002-04-01" @default.
- W378068919 modified "2023-09-29" @default.
- W378068919 title "Antihypertensive properties of Bryophyllum pinnatum $lcurlb;(Lam) Oken$rcurlb; leaf extracts" @default.
- W378068919 doi "https://doi.org/10.1016/s0895-7061(02)02353-1" @default.
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