Matches in SemOpenAlex for { <https://semopenalex.org/work/W3783758> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3783758 endingPage "21" @default.
- W3783758 startingPage "917" @default.
- W3783758 abstract "The application of eye drops is known to be problematic due to the high variability of eye drop volume, the low capacity of the precorneal area resulting in an optimal drop volume of about 20 microl, and the risk of adverse systemic effects of drugs due to systemic absorption via the nasal mucosa. While dropper tip design and the surface activity of the antimicrobial preservative strongly influence the volume of an aqueous ophthalmic solution dispensed as eye drops, the handling of the preparation (dispensing angle, dispensing rate, and the residual volume of liquid in the dropper bottle) is generally believed to produce a minimal effect. In this study, properties of two dropper tips (rubber and plastic) frequently used in the Czech Republic were systematically investigated in a fractional factorial experiment. Of seven determinants potentially influencing the size of eye drops, the dropper tip design, the dispensing angle and the dispensing rate have been found to have a significant effect on the eye drop volume. Wetting of the rubber dropper tip resulted in a dramatic increase in drop volume which could hardly be foreseen in real drop dispensing. As a result, therefore, rubber dropper tips could scarcely be recommended, as opposed to plastic dropper tips which produced drops of comparable volume when used in upright position with approximately the same dispensing rate. Under those defined dispensing conditions, the variability of the drop volume could be expressed by a variability coefficient of 3.3%. Using a dispensing angle of 45 degrees from horizontal led to a decrease in drop volume and, in addition, to greater volume variability due to the formation of air bubbles inside the dropper tip chamber." @default.
- W3783758 created "2016-06-24" @default.
- W3783758 creator A5009482253 @default.
- W3783758 creator A5019693201 @default.
- W3783758 date "2005-12-01" @default.
- W3783758 modified "2023-10-16" @default.
- W3783758 title "Systematic study of factors affecting eye drop size and dosing variability." @default.
- W3783758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16398268" @default.
- W3783758 hasPublicationYear "2005" @default.
- W3783758 type Work @default.
- W3783758 sameAs 3783758 @default.
- W3783758 citedByCount "4" @default.
- W3783758 countsByYear W37837582012 @default.
- W3783758 countsByYear W37837582018 @default.
- W3783758 crossrefType "journal-article" @default.
- W3783758 hasAuthorship W3783758A5009482253 @default.
- W3783758 hasAuthorship W3783758A5019693201 @default.
- W3783758 hasConcept C118487528 @default.
- W3783758 hasConcept C121332964 @default.
- W3783758 hasConcept C127413603 @default.
- W3783758 hasConcept C134514944 @default.
- W3783758 hasConcept C136229726 @default.
- W3783758 hasConcept C159985019 @default.
- W3783758 hasConcept C176933379 @default.
- W3783758 hasConcept C185592680 @default.
- W3783758 hasConcept C192562407 @default.
- W3783758 hasConcept C20556612 @default.
- W3783758 hasConcept C2777625524 @default.
- W3783758 hasConcept C2781345722 @default.
- W3783758 hasConcept C32236832 @default.
- W3783758 hasConcept C71924100 @default.
- W3783758 hasConcept C78519656 @default.
- W3783758 hasConcept C97355855 @default.
- W3783758 hasConceptScore W3783758C118487528 @default.
- W3783758 hasConceptScore W3783758C121332964 @default.
- W3783758 hasConceptScore W3783758C127413603 @default.
- W3783758 hasConceptScore W3783758C134514944 @default.
- W3783758 hasConceptScore W3783758C136229726 @default.
- W3783758 hasConceptScore W3783758C159985019 @default.
- W3783758 hasConceptScore W3783758C176933379 @default.
- W3783758 hasConceptScore W3783758C185592680 @default.
- W3783758 hasConceptScore W3783758C192562407 @default.
- W3783758 hasConceptScore W3783758C20556612 @default.
- W3783758 hasConceptScore W3783758C2777625524 @default.
- W3783758 hasConceptScore W3783758C2781345722 @default.
- W3783758 hasConceptScore W3783758C32236832 @default.
- W3783758 hasConceptScore W3783758C71924100 @default.
- W3783758 hasConceptScore W3783758C78519656 @default.
- W3783758 hasConceptScore W3783758C97355855 @default.
- W3783758 hasIssue "12" @default.
- W3783758 hasLocation W37837581 @default.
- W3783758 hasOpenAccess W3783758 @default.
- W3783758 hasPrimaryLocation W37837581 @default.
- W3783758 hasRelatedWork W1981537050 @default.
- W3783758 hasRelatedWork W1983164716 @default.
- W3783758 hasRelatedWork W1986180285 @default.
- W3783758 hasRelatedWork W1996853317 @default.
- W3783758 hasRelatedWork W2002270025 @default.
- W3783758 hasRelatedWork W2004539400 @default.
- W3783758 hasRelatedWork W2013242195 @default.
- W3783758 hasRelatedWork W2019920104 @default.
- W3783758 hasRelatedWork W2023903257 @default.
- W3783758 hasRelatedWork W2053167406 @default.
- W3783758 hasRelatedWork W2054001210 @default.
- W3783758 hasRelatedWork W2082276469 @default.
- W3783758 hasRelatedWork W2084363217 @default.
- W3783758 hasRelatedWork W2109077016 @default.
- W3783758 hasRelatedWork W2110125079 @default.
- W3783758 hasRelatedWork W2125367046 @default.
- W3783758 hasRelatedWork W2241610891 @default.
- W3783758 hasRelatedWork W46341933 @default.
- W3783758 hasRelatedWork W67842310 @default.
- W3783758 hasRelatedWork W2745662962 @default.
- W3783758 hasVolume "60" @default.
- W3783758 isParatext "false" @default.
- W3783758 isRetracted "false" @default.
- W3783758 magId "3783758" @default.
- W3783758 workType "article" @default.