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- W38263071 endingPage "328" @default.
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- W38263071 abstract "This chapter discusses the concept of directed cell-surface plasminogen activation. Activation occurring on the solid phase of either the cell surface, in the case of the urokinase-type plasminogen activator (u-PA) pathway, or endothelial cells and the fibrin substrate of thrombi in the tissue-type plasminogen activator pathway (t-PA) has the advantage of escaping from the soluble plasmin inhibitors presented in great abundance in extracellular fluids. Receptor-bound pro-u-PA at focal contacts and the more uniformly distributed vitronectin-bound plasminogen activator inhibitor type 1 (PAI-1) on the pericellular substratum are the key determinants in the generation of directed cell-surface–bound plasmin activity. Given the generalized distribution pattern of plasminogen, it is clear that the u-PA receptor (u-PA-R) has a dominant role in directing proteolytic activity at the critical sites of contacts between cells and substratum. Receptor-bound active u-PA is clearly accessible to inhibition by PAI-1 and plasminogen activator inhibitor type 2 (PAI-2). The mechanism that targets u-PA receptors to the focal contact sites is poorly understood at present and needs further investigation as does the analysis of interactions between the components of the extracellular matrix and the proteolytic machinery." @default.
- W38263071 created "2016-06-24" @default.
- W38263071 creator A5024623241 @default.
- W38263071 creator A5049156695 @default.
- W38263071 creator A5056645051 @default.
- W38263071 date "1991-01-01" @default.
- W38263071 modified "2023-09-24" @default.
- W38263071 title "Directed Plasminogen Activation at the Surface of Normal and Malignant Cells" @default.
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