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• W3849076 abstract "Research Article1 July 1991free access Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity. T. Braun T. Braun Laboratory of Molecular Neuroendocrinology, University of Heidelberg, FRG. Search for more papers by this author P.R. Schofield P.R. Schofield Laboratory of Molecular Neuroendocrinology, University of Heidelberg, FRG. Search for more papers by this author R. Sprengel R. Sprengel Laboratory of Molecular Neuroendocrinology, University of Heidelberg, FRG. Search for more papers by this author T. Braun T. Braun Laboratory of Molecular Neuroendocrinology, University of Heidelberg, FRG. Search for more papers by this author P.R. Schofield P.R. Schofield Laboratory of Molecular Neuroendocrinology, University of Heidelberg, FRG. Search for more papers by this author R. Sprengel R. Sprengel Laboratory of Molecular Neuroendocrinology, University of Heidelberg, FRG. Search for more papers by this author Author Information T. Braun1, P.R. Schofield1 and R. Sprengel1 1Laboratory of Molecular Neuroendocrinology, University of Heidelberg, FRG. The EMBO Journal (1991)10:1885-1890https://doi.org/10.1002/j.1460-2075.1991.tb07714.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Recombinant expression of truncated receptors for luteinizing hormone/chorionic gonadotropin (LH/CG) revealed that the amino-terminal leucine-rich repeats 1–8 of the extracellular receptor domain bind human chorionic gonadotropin (hCG) with an affinity (Kd = 0.72 +/− 0.2 nM) similar to that of the native LH/CG receptor (Kd = 0.48 +/− 0.05 nM). LH/CG receptor leucine-rich repeats 1–8 were used to replace homologous sequences in the closely related receptor for follicle stimulating hormone (FSH). Cells expressing such chimeric LH/CG-FSH receptors bind hCG and show elevated cylic AMP levels when stimulated by hCG but not by recombinant human FSH (rhFSH). Similarly, a chimeric LH/CG receptor in which leucine-rich repeats 1–11 originated from the FSH receptor is activated by rhFSH but not by hCG. For this chimera, no residual [125I] hCG binding was observed in a range of 2 pM to 10 nM. Our results demonstrate that specificity of gonadotropin receptors is determined by a high affinity hormone binding site formed by the amino-terminal leucine-rich receptor repeats. Previous ArticleNext Article Volume 10Issue 71 July 1991In this issue RelatedDetailsLoading ..." @default.
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• W3849076 title "Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity." @default.
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• W3849076 doi "https://doi.org/10.1002/j.1460-2075.1991.tb07714.x" @default.
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