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• W38505941 endingPage "67" @default.
• W38505941 startingPage "13" @default.
• W38505941 abstract "Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 1. Selection of ltigh-Production Strains of S. aureq[aciens and S. rimosus 15 a) Mutagen Treatment . . . . . . . . . . . . . . . . . . . . . 15 b) Selection in Mutant Populations . . . . . . . . . . . . . . . . 17 c) Hybridization . . . . . . . . . . . . . . . . . . . . . . . . 18 d) Transduetion . . . . . . . . . . . . . . . . . . . . . . . . 21 e) Increase of Resistance to its Own Metabolite . . . . . . . . . . 2I 2. Isolation and Characterization of Mutants Blocked in the Biosynthesis of Tetracycline Antibiotics . . . . . . . . . . . . . . . . . . . 22 a) Mutant Metabolites of S. aureofaciens . . . . . . . . . . . . . 24 b) Mutant Metabolites of S. rimosus . . . . . . . . . . . . . . . 31 c) Interspecific Cosynthesis . . . . . . . . . . . . . . . . . . . . 35 3. Genetic Recombination . . . . . . . . . . . . . . . . . . . . . 35 a) The Linkage Map of S. rimosus . . . . . . . . . . . . . . . . 36 b) Analysis of Loci Controlling Tetracycline Biosynthesis . . . . . . 38 c) Interspecific Recombination . . . . . . . . . . . . . . . . . . 44 4. Genetic Control of the Biosynthetic Process . . . . . . . . . . . . 44 a) Genes Responsible for the Biosynthesis of Tetracyclines . . . . . . 44 b) Quantitative Aspects of the Biosynthesis of Tetracyclines . . . . . 56 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . 60 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63" @default.
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• W38505941 date "1974-01-01" @default.
• W38505941 modified "2023-10-17" @default.
• W38505941 title "Genetic problems of the biosynthesis of tetracycline antibiotics" @default.
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• W38505941 doi "https://doi.org/10.1007/3-540-06546-6_2" @default.
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