Matches in SemOpenAlex for { <https://semopenalex.org/work/W38562357> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W38562357 abstract "Although neuroactive steroids protects against experimental seizures, the role of GABA-A receptor-modulating neuroactive steroids in the development and expression of amygdala kindling remains unclear. In this study, the neuroactive steroid ganaxolone was examined on behavioral and electrographic seizure expression in the amygdala kindling model of epilepsy in mice, and the protective activity was compared with the antiseizure benzodiazepine clonazepam. Mice were kindled by daily stimulation of amygdala until they exhibit consistent behavioral and electrographic seizures. In fully kindled mice showing stage 5 seizures, ganaxolone (1.25-20 mg/kg, s.c.) significantly reduced both clonic and generalized seizures elicited by amygdala stimulation. The protective effect of ganaxolone was dose-dependent with an ED50 of 6.6 mg/kg. Ganaxolone treatment was associated with significant reduction in the afterdischarge duration. As expected, there was a substantial suppression of behavioral and electrographic seizures in mice treated with clonazepam. Clonazepam was more potent than ganaxolone, but the overall maximal efficacy of both clonazepam and ganaxolone was similar. These studies provide strong evidence that ganaxolone is highly effective antiseizure agent in the amygdala kindling model, which is a clinically-relevant model of complex partial epilepsy." @default.
- W38562357 created "2016-06-24" @default.
- W38562357 creator A5004551722 @default.
- W38562357 creator A5077360961 @default.
- W38562357 date "2009-04-01" @default.
- W38562357 modified "2023-09-26" @default.
- W38562357 title "Protective Efficacy and Potency of Neuroactive Steroids and Benzodiazepines in the Amygdala Kindling Model of Epilepsy" @default.
- W38562357 doi "https://doi.org/10.1096/fasebj.23.1_supplement.947.6" @default.
- W38562357 hasPublicationYear "2009" @default.
- W38562357 type Work @default.
- W38562357 sameAs 38562357 @default.
- W38562357 citedByCount "0" @default.
- W38562357 crossrefType "journal-article" @default.
- W38562357 hasAuthorship W38562357A5004551722 @default.
- W38562357 hasAuthorship W38562357A5077360961 @default.
- W38562357 hasConcept C100691959 @default.
- W38562357 hasConcept C118552586 @default.
- W38562357 hasConcept C126322002 @default.
- W38562357 hasConcept C168258287 @default.
- W38562357 hasConcept C170493617 @default.
- W38562357 hasConcept C2778173252 @default.
- W38562357 hasConcept C2778186239 @default.
- W38562357 hasConcept C2778302826 @default.
- W38562357 hasConcept C2779144063 @default.
- W38562357 hasConcept C2779426884 @default.
- W38562357 hasConcept C44796713 @default.
- W38562357 hasConcept C71924100 @default.
- W38562357 hasConcept C98274493 @default.
- W38562357 hasConceptScore W38562357C100691959 @default.
- W38562357 hasConceptScore W38562357C118552586 @default.
- W38562357 hasConceptScore W38562357C126322002 @default.
- W38562357 hasConceptScore W38562357C168258287 @default.
- W38562357 hasConceptScore W38562357C170493617 @default.
- W38562357 hasConceptScore W38562357C2778173252 @default.
- W38562357 hasConceptScore W38562357C2778186239 @default.
- W38562357 hasConceptScore W38562357C2778302826 @default.
- W38562357 hasConceptScore W38562357C2779144063 @default.
- W38562357 hasConceptScore W38562357C2779426884 @default.
- W38562357 hasConceptScore W38562357C44796713 @default.
- W38562357 hasConceptScore W38562357C71924100 @default.
- W38562357 hasConceptScore W38562357C98274493 @default.
- W38562357 hasIssue "S1" @default.
- W38562357 hasLocation W385623571 @default.
- W38562357 hasOpenAccess W38562357 @default.
- W38562357 hasPrimaryLocation W385623571 @default.
- W38562357 hasRelatedWork W1055347615 @default.
- W38562357 hasRelatedWork W1508849773 @default.
- W38562357 hasRelatedWork W1624131557 @default.
- W38562357 hasRelatedWork W1988931452 @default.
- W38562357 hasRelatedWork W2086909289 @default.
- W38562357 hasRelatedWork W2165699104 @default.
- W38562357 hasRelatedWork W2387011992 @default.
- W38562357 hasRelatedWork W2416745555 @default.
- W38562357 hasRelatedWork W2906808516 @default.
- W38562357 hasRelatedWork W2980527401 @default.
- W38562357 hasVolume "23" @default.
- W38562357 isParatext "false" @default.
- W38562357 isRetracted "false" @default.
- W38562357 magId "38562357" @default.
- W38562357 workType "article" @default.