FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W386431711> ?p ?o ?g. }

• W386431711 endingPage "54" @default.
• W386431711 startingPage "48" @default.
• W386431711 abstract "The blood brain barrier (BBB) is composed of endothelial cells, astrocytes, and pericytes and maintains functional homeostasis by regulating transport of ions, fluid and cells between blood and neural tissue. The cellular and molecular pathways that contribute to the formation of the BBB in the developing brain have not been fully deciphered. β1-integrin (β1-itg) within endothelial cells is known to play a critical role in vasculogenesis. However, the role of astrocytic β1-itg in BBB development is not known. Our study used a mouse glial fibrillary acidic protein (GFAP)-cre transgenic line to selectively ablate β1-itg within astrocytes. We found that deletion of astrocytic β1-itg had a striking effect on the different cell types that form the BBB. Mutant mice had a decreased density of aquaporin-4 immunoreactivity within the perivascular astrocytic end-feet. We also found decreases in immunoreactivity for vimentin and CD-31 within endothelial cells. These changes were not accompanied by functional changes in BBB under physiological conditions as assessed by extravasation of large and small molecular weight molecules. However, mutant mice had an increased incidence of severe cystic injury in response to neonatal hypoxia. Our findings show that astrocytic β1-itg has an important role in defining cellular properties of the blood brain barrier in the cerebral cortex." @default.
• W386431711 created "2016-06-24" @default.
• W386431711 creator A5027108812 @default.
• W386431711 creator A5029832154 @default.
• W386431711 creator A5030490799 @default.
• W386431711 creator A5049362276 @default.
• W386431711 date "2015-05-19" @default.
• W386431711 modified "2023-10-15" @default.
• W386431711 title "Astrocytic β1‐integrin affects cellular composition of murine blood brain barrier in the cerebral cortex" @default.
• W386431711 cites W1533942347 @default.
• W386431711 cites W1535419310 @default.
• W386431711 cites W1543151032 @default.
• W386431711 cites W1549213315 @default.
• W386431711 cites W1576773659 @default.
• W386431711 cites W1978008817 @default.
• W386431711 cites W1980471744 @default.
• W386431711 cites W1980543293 @default.
• W386431711 cites W1986094463 @default.
• W386431711 cites W1992758695 @default.
• W386431711 cites W1995857537 @default.
• W386431711 cites W1998709931 @default.
• W386431711 cites W2008336268 @default.
• W386431711 cites W2020543532 @default.
• W386431711 cites W2030282028 @default.
• W386431711 cites W2059994807 @default.
• W386431711 cites W2060188196 @default.
• W386431711 cites W2068083739 @default.
• W386431711 cites W2076503648 @default.
• W386431711 cites W2085424855 @default.
• W386431711 cites W2090874298 @default.
• W386431711 cites W2103692236 @default.
• W386431711 cites W2118737843 @default.
• W386431711 cites W2120243513 @default.
• W386431711 cites W2121860798 @default.
• W386431711 cites W2124143346 @default.
• W386431711 cites W2128894005 @default.
• W386431711 cites W2167590613 @default.
• W386431711 cites W2167739272 @default.
• W386431711 doi "https://doi.org/10.1016/j.ijdevneu.2015.05.005" @default.
• W386431711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25997909" @default.
• W386431711 hasPublicationYear "2015" @default.
• W386431711 type Work @default.
• W386431711 sameAs 386431711 @default.
• W386431711 citedByCount "10" @default.
• W386431711 countsByYear W3864317112016 @default.
• W386431711 countsByYear W3864317112018 @default.
• W386431711 countsByYear W3864317112019 @default.
• W386431711 countsByYear W3864317112022 @default.
• W386431711 crossrefType "journal-article" @default.
• W386431711 hasAuthorship W386431711A5027108812 @default.
• W386431711 hasAuthorship W386431711A5029832154 @default.
• W386431711 hasAuthorship W386431711A5030490799 @default.
• W386431711 hasAuthorship W386431711A5049362276 @default.
• W386431711 hasConcept C102230213 @default.
• W386431711 hasConcept C104317684 @default.
• W386431711 hasConcept C136834591 @default.
• W386431711 hasConcept C141035611 @default.
• W386431711 hasConcept C147447768 @default.
• W386431711 hasConcept C15755913 @default.
• W386431711 hasConcept C169760540 @default.
• W386431711 hasConcept C203014093 @default.
• W386431711 hasConcept C204232928 @default.
• W386431711 hasConcept C2777542381 @default.
• W386431711 hasConcept C2778402981 @default.
• W386431711 hasConcept C2779540182 @default.
• W386431711 hasConcept C2780495277 @default.
• W386431711 hasConcept C2781041448 @default.
• W386431711 hasConcept C28328180 @default.
• W386431711 hasConcept C529278444 @default.
• W386431711 hasConcept C55493867 @default.
• W386431711 hasConcept C86803240 @default.
• W386431711 hasConcept C95444343 @default.
• W386431711 hasConceptScore W386431711C102230213 @default.
• W386431711 hasConceptScore W386431711C104317684 @default.
• W386431711 hasConceptScore W386431711C136834591 @default.
• W386431711 hasConceptScore W386431711C141035611 @default.
• W386431711 hasConceptScore W386431711C147447768 @default.
• W386431711 hasConceptScore W386431711C15755913 @default.
• W386431711 hasConceptScore W386431711C169760540 @default.
• W386431711 hasConceptScore W386431711C203014093 @default.
• W386431711 hasConceptScore W386431711C204232928 @default.
• W386431711 hasConceptScore W386431711C2777542381 @default.
• W386431711 hasConceptScore W386431711C2778402981 @default.
• W386431711 hasConceptScore W386431711C2779540182 @default.
• W386431711 hasConceptScore W386431711C2780495277 @default.
• W386431711 hasConceptScore W386431711C2781041448 @default.
• W386431711 hasConceptScore W386431711C28328180 @default.
• W386431711 hasConceptScore W386431711C529278444 @default.
• W386431711 hasConceptScore W386431711C55493867 @default.
• W386431711 hasConceptScore W386431711C86803240 @default.
• W386431711 hasConceptScore W386431711C95444343 @default.
• W386431711 hasFunder F4320309098 @default.
• W386431711 hasIssue "1" @default.
• W386431711 hasLocation W3864317111 @default.
• W386431711 hasLocation W3864317112 @default.
• W386431711 hasOpenAccess W386431711 @default.
• W386431711 hasPrimaryLocation W3864317111 @default.
• W386431711 hasRelatedWork W1985183218 @default.

• next