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- W38691235 abstract "High levels of genetic variability are associated with HIV since the virus has been first sequenced. It is recognized at an early stage that this variability could have a major impact on the efficacy of any vaccine and this was the original motivation for much of the work on viral variation. More recently it is recognized as being integral to analysis of immunological responses to HIV infection of transmission, pathogenesis, drug resistance, and epidemiology. The view of the genetics of HIV populations that has dominated the field is strongly influenced by the extremely large numbers of particles circulating in the plasma, and the suggestion that very large numbers of cells in solid lymphoid tissue may harbor proviruses. The appropriate theory for such a large population is deterministic and this is developed both in models of the interaction with the immune system and in regard to the important implications for variation at synonymous sites. However, in many respects the evolution of HIV, even in response to a defined selection pressure, is less predictable than expected from a deterministic model." @default.
- W38691235 created "2016-06-24" @default.
- W38691235 creator A5084345521 @default.
- W38691235 date "1999-01-01" @default.
- W38691235 modified "2023-09-25" @default.
- W38691235 title "Viral Evolution and Variation in the HIV Pandemic" @default.
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- W38691235 doi "https://doi.org/10.1016/b978-012200741-5/50004-0" @default.
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