Matches in SemOpenAlex for { <https://semopenalex.org/work/W38698841> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W38698841 endingPage "1532" @default.
- W38698841 startingPage "1532" @default.
- W38698841 abstract "<b>Background:</b> Concern exists that the prolonged application of immunomodulators to treat atopic dermatitis may cause systemic immunosuppression. <b>Aims:</b> In a 7-month, multicentre, randomised, controlled trial, we investigated the equivalence of response to vaccination against meningococcal serogroup C disease with a protein-conjugate vaccine in children (2–11 years) with moderate to severe atopic dermatitis, by applying either 0.03% tacrolimus ointment (TAC-O; n = 21) or a hydrocortisone ointment regimen (HC-O; n = 111). <b>Methods:</b> TAC-O was applied twice daily (bid) for 3 weeks, and thereafter daily until clearance. 1% hydrocortisone acetate (HA) for head/neck and 0.1% hydrocortisone butyrate ointment for trunk/limbs was applied bid for 2 weeks; thereafter HA was applied bid to all affected areas. At week 1, patients were vaccinated with protein-conjugate vaccine against meningococcal serogroup C, and challenged at month 6 with low dose meningococcal polysaccharide vaccine. The control group (44 non-atopic dermatatits children) received the primary vaccination and challenge dose. Assessments were made at baseline, weeks 1 and 5, and months 6 and 7. The primary end point was the percentage of patients with a serum bactericidal antibody (SBA) titre ⩾8 at the week 5 visit. <b>Results:</b> The response rate (patients with SBA titre ⩾8) was 97.5% (confidence interval (CI) approximately 97.3 to 100), 99.1% (94.8 to 100) and 97.7% (93.3 to 100) in the TAC-O, HC-O and control groups, respectively. <b>Conclusions:</b> The immune response to vaccination against meningococcal serogroup C in children with atopic dermatitis applying either 0.03% TAC-O or HC is equivalent. Ointment application does not affect the immediate response to vaccination, generation of immune memory or humoral and cell-mediated immunity." @default.
- W38698841 created "2016-06-24" @default.
- W38698841 creator A5031019629 @default.
- W38698841 date "1995-06-10" @default.
- W38698841 modified "2023-09-25" @default.
- W38698841 title "Recruiting ethnic minority medical students" @default.
- W38698841 cites W2021538682 @default.
- W38698841 cites W2055549027 @default.
- W38698841 doi "https://doi.org/10.1136/bmj.310.6993.1532" @default.
- W38698841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2549894" @default.
- W38698841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7661958" @default.
- W38698841 hasPublicationYear "1995" @default.
- W38698841 type Work @default.
- W38698841 sameAs 38698841 @default.
- W38698841 citedByCount "1" @default.
- W38698841 crossrefType "journal-article" @default.
- W38698841 hasAuthorship W38698841A5031019629 @default.
- W38698841 hasBestOaLocation W386988412 @default.
- W38698841 hasConcept C126322002 @default.
- W38698841 hasConcept C159654299 @default.
- W38698841 hasConcept C168563851 @default.
- W38698841 hasConcept C203014093 @default.
- W38698841 hasConcept C22070199 @default.
- W38698841 hasConcept C2777785397 @default.
- W38698841 hasConcept C2780454893 @default.
- W38698841 hasConcept C2780801004 @default.
- W38698841 hasConcept C2781413609 @default.
- W38698841 hasConcept C71924100 @default.
- W38698841 hasConcept C90924648 @default.
- W38698841 hasConceptScore W38698841C126322002 @default.
- W38698841 hasConceptScore W38698841C159654299 @default.
- W38698841 hasConceptScore W38698841C168563851 @default.
- W38698841 hasConceptScore W38698841C203014093 @default.
- W38698841 hasConceptScore W38698841C22070199 @default.
- W38698841 hasConceptScore W38698841C2777785397 @default.
- W38698841 hasConceptScore W38698841C2780454893 @default.
- W38698841 hasConceptScore W38698841C2780801004 @default.
- W38698841 hasConceptScore W38698841C2781413609 @default.
- W38698841 hasConceptScore W38698841C71924100 @default.
- W38698841 hasConceptScore W38698841C90924648 @default.
- W38698841 hasIssue "6993" @default.
- W38698841 hasLocation W386988411 @default.
- W38698841 hasLocation W386988412 @default.
- W38698841 hasLocation W386988413 @default.
- W38698841 hasLocation W386988414 @default.
- W38698841 hasOpenAccess W38698841 @default.
- W38698841 hasPrimaryLocation W386988411 @default.
- W38698841 hasRelatedWork W2007153246 @default.
- W38698841 hasRelatedWork W2007717858 @default.
- W38698841 hasRelatedWork W2031158406 @default.
- W38698841 hasRelatedWork W2089045987 @default.
- W38698841 hasRelatedWork W2331247294 @default.
- W38698841 hasRelatedWork W2354225813 @default.
- W38698841 hasRelatedWork W3118107215 @default.
- W38698841 hasRelatedWork W3152343337 @default.
- W38698841 hasRelatedWork W3159250744 @default.
- W38698841 hasRelatedWork W4256514411 @default.
- W38698841 hasVolume "310" @default.
- W38698841 isParatext "false" @default.
- W38698841 isRetracted "false" @default.
- W38698841 magId "38698841" @default.
- W38698841 workType "article" @default.