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- W38767550 abstract "To investigate the efficacy, adverse events and long-term survival of cyclophosphamide, vindesine, cytarabine, dexamethasone and bleomycin (COAD-B) regimen for relapsed and refractory non-Hodgkin lymphoma (NHL).Eighty six patients diagnosed with relapsed or refractory NHL were included in our study from January 2007 to January 2013. The chemotherapy regimen was COAD-B, the therapeutic efficacy was evaluated every 2 courses. Once the stable disease (SD) or progress of the disease (PD) achieved, the patients would switch to other second-line regimens.The overall response rate (ORR) was 67.4%, median remission duration was 13 months (3-51 months); 1-,2- and 4-year overall survival (OS) rates were 75.4%, 56.8% and 40.0%, respectively; 1-, 2- and 4-year progression-free survival (PFS) rates were 50.3%, 39.4% and 27.5%, respectively. The main adverse reaction of patients was myelosuppression. The response to chemotherapy and long- term survival of the relapsed patients were significantly better than that of the refractory ones, and the difference had statistical significance.COAD-B could be the salvage regimen for relapsed and refractory NHL." @default.
- W38767550 created "2016-06-24" @default.
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- W38767550 date "2013-10-01" @default.
- W38767550 modified "2023-10-14" @default.
- W38767550 title "[Clinical study of COAD-B regimen in treatment of patients with relapsed/refractory non-Hodgkin lymphoma]." @default.
- W38767550 doi "https://doi.org/10.3760/cma.j.issn.0253-2727.2013.10.007" @default.
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