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- W38814114 abstract "This chapter discusses the suppressor cells regulating the in vivo induction of cytotoxic T lymphocytes (CTL) and of memory cells for a secondary in vitro CMC response. CTL are assumed to play a key role in graft rejection and to be potentially important for the host defense against the tumors. Potent in vivo activation occurs in mice in response to solid-tissue allografts but does not occur after injection of allogenic or TNP-coupled spleen cells into the footpads, although such injection can activate memory cells that produce a powerful secondary cell-mediated cytotoxicity response in vitro. The chapter describes an experiment in which mice treated only with CyP and not with TNCB showed background DNA-synthesis in the lymph nodes of less than 10 × 10 and no CTL-responses. Mice that were skin-painted with TNCB but not pretreated with CyP showed an initial small DNA-synthesis response in the lymph nodes that returned to background values by day 5. It was found that these mice did not produce a detectable CTL response." @default.
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- W38814114 date "1979-01-01" @default.
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- W38814114 title "SUPPRESSOR CELLS REGULATING THE IN VIVO INDUCTION OF CYTOTOXIC T LYMPHOCYTES AND OF MEMORY CELLS FOR A SECONDARY IN VITRO CMC RESPONSE" @default.
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- W38814114 doi "https://doi.org/10.1016/b978-0-12-569650-0.50063-2" @default.
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