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- W388886068 abstract "A 60-year old woman was admitted for reintroduction of interferon/ribavirin combination therapy to prevent the recurrence of hepatitis C following living donor liver transplantation (LDLT). She had also undergone splenectomy during LDLT to avoid postoperative pancytopenia due to hypersplenism. However, a few days after reintroduction of the therapy, she developed severe diarrhea and fever that progressed to circulatory and respiratory shock. Blood culture was positive for Streptococcus pneumoniae, leading to a diagnosis of overwhelming postsplenectomy infection (OPSI). Although the patient developed multi-organ failure, she ultimately recovered after intensive care including mechanical ventilation and hemodialysis. Once OPSI is suspected, intensive care should be commenced immediately given the disease' s fulminant clinical course and high mortality. Postoperative prophylaxis with the pneumococcal vaccine needs to be tested in a multi-center study." @default.
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- W388886068 date "2015-02-01" @default.
- W388886068 modified "2023-09-25" @default.
- W388886068 title "[Overwhelming postsplenectomy infection during combination therapy with interferon ribavirin after living donor liver transplantation for hepatitis C: a case report]." @default.
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- W388886068 doi "https://doi.org/10.11405/nisshoshi.112.325" @default.
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