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- W390735232 abstract "This chapter presents an overview of physiocontrol microsystem. A research group is developing a flow-through chamber with various (bio) sensors to monitor the physiological state of immobilized cells or tissues. The monitoring of concentrations of various ions, enzymes, antigens, antibodies and other cell metabolites, or cell affecting agents requires a special measuring system which affects the living cells or tissues in the measuring chamber as little as possible. Quick response of the sensors at very small sample volumes necessitates short diffusion distances from cell to sensor. With computer simulations of cell mechanisms and signal pathways, the most appropriate parameters of measurement can be selected, therefore assisting the evaluation of the measured signal for monitoring the physiological state of the cells. The most suitable parameters of measurement depend of course on the availability of the necessary (bio) sensors and the possibility of integration of the sensor in the flow-through chamber in combination with other sensors. Therefore, the group is developing and testing a range of optical and electrical (bio)sensors as well as various designs of the flow-through chamber in cooperation with other groups to determine whether these designs match requirements for the physiocontrol microsystem." @default.
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- W390735232 date "1994-01-01" @default.
- W390735232 modified "2023-09-27" @default.
- W390735232 title "The Physiocontrol Microsystem" @default.
- W390735232 doi "https://doi.org/10.1016/b978-1-85617-242-4.50275-5" @default.
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