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- W391039763 abstract "# Springer-Verlag 2007 Summary Object. To assess whether nimustine (ACNU), a drug that can cross the blood brain barrier, combined with radiotherapy, improved the survival of patients with primary central nervous system lymphoma (PCNSL). Clinical materials and methods. Between 1995 and 2005, we treated 63 immunocompetent PCNSL patients with combination therapy consisting of intra-arterial ACNU (100 mg=m 2 ) and whole brain radiotherapy (36–50 Gy). Their median age was 60 years (range 28–81). The median follow-up was 24 months. Findings. With this regimen we achieved a complete response rate of 75% (43 of 57 patients). Kaplan–Meier estimates for median progression-free survival and median overall survival were 26 and 39 months, respectively. The 3- and 5-year survival rates were 51% (95% confidence interval [CI], 36–65%) and 32% (95% CI, 17–47%), respectively. By multivariate analysis, age ( 60) was associated with a high risk of neurotoxicity. Conclusion. The intra-arterial administration of ACNU combined with radiation therapy yielded a high response rate at acceptable toxicity levels in younger patients with PCNSL. However, late neurotoxicity was a serious complication in patients above 60 years of age." @default.
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- W391039763 date "2007-01-01" @default.
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- W391039763 title "Brief Report of Special Case Primary CNS lymphoma treated with combined intra-arterial ACNU and radiotherapy" @default.
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