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- W39178879 abstract "Recently, it was shown that pacemaker f/HCN channel might be permeable not only for Na+ and K+, but also for calcium ions. Pacemaker channel HCN2 was expressed in ovarian cell culture of Chinese hamster. In the patch clamp experiments the calcium current with low amplitude 0.06±-0.87 nA and open probability 0.48% (±3.02 at -110 mV, n = 6, Ca2+ 2 mmol) was measured. HCN2-Ca2+ current significantly activated with cyclic adenosinemonophosphate by increasing of open probability and inhibited by specific If-blocker ivabradine. The calcium ion current was also shown in f-channels of neonatal rats ventriculocytes. Thus, the calcium ions conduction through HCN2 and native f-channel at physiological concentrations of extracellular fluid and physiological membrane potentials of cardiomyocytes was demonstrated." @default.
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- W39178879 date "2013-10-01" @default.
- W39178879 modified "2023-09-23" @default.
- W39178879 title "[Direct evidences of calcium traffic through pacemaker channel]." @default.
- W39178879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25507827" @default.
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