Matches in SemOpenAlex for { <https://semopenalex.org/work/W39237657> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W39237657 endingPage "47" @default.
- W39237657 startingPage "329" @default.
- W39237657 abstract "The Peripheral Arterial Vasodilation hypothesis most completely explains the clinical spectrum of cirrhosis ranging from compensated to decompensated to the hepatorenal syndrome (Figure 15-1). As the systemic peripheral vasodilation increases, the neurohumoral responses to arterial underfilling are stimulated with resultant renal vasoconstriction, sodium and water retention. Hypoalbuminemia and portal hypertension, as well as local effects of vasodilation at the capillary level, also contribute to ascites formation and peripheral edema. The suppressed plasma renin activity and aldosterone concentrations and exaggerated natriuresis, which are observed in some patients with early cirrhosis during HWI and the supine position, probably indicate greater central translocation of splanchnic fluid in these volume expanded cirrhotic patients when compared with normal subjects. This interpretation is supported by the greater increases in ANF during HWI in these patients when compared with controls. The neurohumoral responses to arterial vasodilation in cirrhosis combine to decrease distal sodium and water delivery, an event which impairs escape from the sodium retaining effects of aldosterone and causes resistance to the distal tubular effect of ANF (Figure 15-3). As discussed, the peripheral arterial vasodilation of cirrhosis is no doubt multifactorial in nature and the resultant arterial underfilling may be worsened by events that could impair the cardiac response to afterload reduction, including bile salt accumulation, alcoholic cardiomyopathy, and tense ascites decreasing cardiac preload. This pathogenetic schema of cirrhosis is compatible with the unifying body fluid volume hypothesis (Figure 15-3), which we have recently proposed." @default.
- W39237657 created "2016-06-24" @default.
- W39237657 creator A5013936557 @default.
- W39237657 creator A5036446781 @default.
- W39237657 date "1992-01-01" @default.
- W39237657 modified "2023-09-23" @default.
- W39237657 title "Pathogenesis of sodium and water retention in liver disease." @default.
- W39237657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1296235" @default.
- W39237657 hasPublicationYear "1992" @default.
- W39237657 type Work @default.
- W39237657 sameAs 39237657 @default.
- W39237657 citedByCount "2" @default.
- W39237657 crossrefType "journal-article" @default.
- W39237657 hasAuthorship W39237657A5013936557 @default.
- W39237657 hasAuthorship W39237657A5036446781 @default.
- W39237657 hasConcept C120770815 @default.
- W39237657 hasConcept C126322002 @default.
- W39237657 hasConcept C134018914 @default.
- W39237657 hasConcept C138976137 @default.
- W39237657 hasConcept C139940330 @default.
- W39237657 hasConcept C164705383 @default.
- W39237657 hasConcept C174459258 @default.
- W39237657 hasConcept C178853913 @default.
- W39237657 hasConcept C197934379 @default.
- W39237657 hasConcept C198710026 @default.
- W39237657 hasConcept C2777214474 @default.
- W39237657 hasConcept C2777482430 @default.
- W39237657 hasConcept C2778525890 @default.
- W39237657 hasConcept C2778808290 @default.
- W39237657 hasConcept C2779065481 @default.
- W39237657 hasConcept C2779961880 @default.
- W39237657 hasConcept C2780496750 @default.
- W39237657 hasConcept C48277249 @default.
- W39237657 hasConcept C58245268 @default.
- W39237657 hasConcept C71924100 @default.
- W39237657 hasConcept C84393581 @default.
- W39237657 hasConceptScore W39237657C120770815 @default.
- W39237657 hasConceptScore W39237657C126322002 @default.
- W39237657 hasConceptScore W39237657C134018914 @default.
- W39237657 hasConceptScore W39237657C138976137 @default.
- W39237657 hasConceptScore W39237657C139940330 @default.
- W39237657 hasConceptScore W39237657C164705383 @default.
- W39237657 hasConceptScore W39237657C174459258 @default.
- W39237657 hasConceptScore W39237657C178853913 @default.
- W39237657 hasConceptScore W39237657C197934379 @default.
- W39237657 hasConceptScore W39237657C198710026 @default.
- W39237657 hasConceptScore W39237657C2777214474 @default.
- W39237657 hasConceptScore W39237657C2777482430 @default.
- W39237657 hasConceptScore W39237657C2778525890 @default.
- W39237657 hasConceptScore W39237657C2778808290 @default.
- W39237657 hasConceptScore W39237657C2779065481 @default.
- W39237657 hasConceptScore W39237657C2779961880 @default.
- W39237657 hasConceptScore W39237657C2780496750 @default.
- W39237657 hasConceptScore W39237657C48277249 @default.
- W39237657 hasConceptScore W39237657C58245268 @default.
- W39237657 hasConceptScore W39237657C71924100 @default.
- W39237657 hasConceptScore W39237657C84393581 @default.
- W39237657 hasLocation W392376571 @default.
- W39237657 hasOpenAccess W39237657 @default.
- W39237657 hasPrimaryLocation W392376571 @default.
- W39237657 hasRelatedWork W1799770855 @default.
- W39237657 hasRelatedWork W1993396385 @default.
- W39237657 hasRelatedWork W2031633633 @default.
- W39237657 hasRelatedWork W2045471268 @default.
- W39237657 hasRelatedWork W2116710690 @default.
- W39237657 hasRelatedWork W2124888129 @default.
- W39237657 hasRelatedWork W2138733345 @default.
- W39237657 hasRelatedWork W2167503593 @default.
- W39237657 hasRelatedWork W2409223910 @default.
- W39237657 hasRelatedWork W39237657 @default.
- W39237657 hasVolume "10" @default.
- W39237657 isParatext "false" @default.
- W39237657 isRetracted "false" @default.
- W39237657 magId "39237657" @default.
- W39237657 workType "article" @default.