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- W39262207 abstract "The t(11;22)(q24;q12) translocation is found in about 85% of the Ewing tumors. In few instances, complex translocations, involving chromosomes 11, 22 and a third chromosome or apparently variant translocations involving another chromosome than chromosome 11 have also been reported. These rearrangements generate an active fusion gene between the EWS gene and the human FLI-1 gene or with another member of the ETS family gene localized in band 21q22, the ERG gene. We report here (1) the use of DIRect Visualisation In Situ Hybridization (DIRVISH) with cosmid probes corresponding to loci flanking or overlapping both 11 and 22 breakpoints for the precise analysis of the classic t(11;22) translocation and (2) the molecular cytogenetic characterization with a set of probes hybridized on interphase nuclei or metaphases of particular ES tumors with a complex t(2;11;22) translocation, an apparently variant t(12;22) translocation, a t(21;22) translocation and two ES tumors without specific rearrangements but with an EWS/ERG fusion gene demonstrated by the molecular analysis. These molecular cytogenetic methods allowed us (1) to precisely localize the genomic breakpoints and the fusion gene, (2) to determine the translocation events generating the fusion genes, and (3) to suggest that variant translocations could be masked complex translocations or involvemore » the ERG gene instead of the human FLI-1 gene.« less" @default.
- W39262207 created "2016-06-24" @default.
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- W39262207 date "1994-09-01" @default.
- W39262207 modified "2023-09-23" @default.
- W39262207 title "Use of bicolor FISH and DIRVISH methods to analyse the breakpoint of translocations in ES/PNE" @default.
- W39262207 hasPublicationYear "1994" @default.
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