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- W39452610 endingPage "1707" @default.
- W39452610 startingPage "1694" @default.
- W39452610 abstract "The internal ribosome entry site (IRES) in the 5′ untranslated region (UTR) of the hepatitis C virus (HCV) genome initiates translation of the viral polyprotein precursor. The unique structure and high sequence conservation of the 5′ UTR render the IRES RNA a potential target for the development of selective viral translation inhibitors. Here, we provide an overview of approaches to block HCV IRES function by nucleic acid, peptide, and small molecule ligands. Emphasis will be given to the IRES subdomain IIa, which currently is the most advanced target for small molecule inhibitors of HCV translation. The subdomain IIa behaves as an RNA conformational switch. Selective ligands act as translation inhibitors by locking the conformation of the RNA switch. We review synthetic procedures for inhibitors as well as structural and functional studies of the subdomain IIa target and its ligand complexes." @default.
- W39452610 created "2016-06-24" @default.
- W39452610 creator A5000646287 @default.
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- W39452610 creator A5079308596 @default.
- W39452610 creator A5090832608 @default.
- W39452610 date "2013-11-05" @default.
- W39452610 modified "2023-10-10" @default.
- W39452610 title "Hepatitis C Virus Translation Inhibitors Targeting the Internal Ribosomal Entry Site" @default.
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