FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W39609980> ?p ?o ?g. }

• W39609980 endingPage "55" @default.
• W39609980 startingPage "1049" @default.
• W39609980 abstract "We studied the presence of peripheral-blood- and bone-marrow-derived T-lymphocyte colony formation (CFU-TL) in 28 bone marrow transplant recipients from 1 month to six years after transplantation. Peripheral blood leukocyte and lymphocyte counts were generally normal, and all had morphologic evidence of engraftment without leukemia at the time of study. Both peripheral-blood- and bone-marrow-derived CFU-TL were markedly reduced after transplantation as compared to normal controls, which included bone marrow donors (14.2 +/- 5/4 X 10(4) vs 313 +/- 100/4 X 10(4) [p less than 0.001] and 26 +/- 4/2 X 10(5) vs 1004 +/- 60/2 X 10(5) [p less than 0.001]). Among the patients, four had no detectable bone-marrow-derived CFU-TL when tested less than six months after transplantation. Peripheral blood CFU-TL, while present in all patients, was markedly decreased for more than 12 months after transplantation. After two years, the number of CFU-TL returned to normal in several patients. The abnormalities in CFU-TL were unrelated to diagnosis, age, sex, graft-versus-host disease (GVHD), pretransplant conditioning, or posttransplant immunosuppressive treatment. Patients receiving autologous bone marrow transplants also had decreased CFU-TL. Cocultures of normal peripheral-blood- or bone-marrow-derived mononuclear cells with recipients' mononuclear cells or sera did not inhibit normal CFU-TL growth. Furthermore, the addition of mononuclear cells or sera from normal individuals, or of exogenous interleukin 1 or interleukin 2, did not correct the deficiency of CFU-TL growth by recipient cells. Depletion of T-lymphocytes from bone marrow or peripheral blood in transplant recipients by physical techniques or with a monoclonal antibody (CT-2) and complement had no effect on CFU-TL recovery. Similarly, addition of recipients' T cells to normal peripheral blood or bone marrow mononuclear cells did not suppress CFU-TL. These data indicate that most transplant recipients have a marked reduction in CFU-TL which persists for up to two years after transplantation. This reduction in the growth of T-cell colonies appears to be due to deficient numbers of these cells or an intrinsic defect in their responsiveness to T-cell lymphokines, rather than a result of growth suppression by inhibitory cells or serum factors. This observed defect in CFU-TL may have implications for therapeutic attempts to facilitate immune reconstitution after bone marrow transplantation." @default.
• W39609980 created "2016-06-24" @default.
• W39609980 creator A5048913229 @default.
• W39609980 creator A5077857608 @default.
• W39609980 creator A5087813701 @default.
• W39609980 creator A5088486180 @default.
• W39609980 date "1986-12-01" @default.
• W39609980 modified "2023-09-23" @default.
• W39609980 title "Abnormal T-lymphocyte colonies (CFU-TL) following bone marrow transplantation." @default.
• W39609980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3536545" @default.
• W39609980 hasPublicationYear "1986" @default.
• W39609980 type Work @default.
• W39609980 sameAs 39609980 @default.
• W39609980 citedByCount "1" @default.
• W39609980 crossrefType "journal-article" @default.
• W39609980 hasAuthorship W39609980A5048913229 @default.
• W39609980 hasAuthorship W39609980A5077857608 @default.
• W39609980 hasAuthorship W39609980A5087813701 @default.
• W39609980 hasAuthorship W39609980A5088486180 @default.
• W39609980 hasConcept C109159458 @default.
• W39609980 hasConcept C126322002 @default.
• W39609980 hasConcept C137061746 @default.
• W39609980 hasConcept C142724271 @default.
• W39609980 hasConcept C202751555 @default.
• W39609980 hasConcept C203014093 @default.
• W39609980 hasConcept C2777761686 @default.
• W39609980 hasConcept C2778461978 @default.
• W39609980 hasConcept C2780007613 @default.
• W39609980 hasConcept C28328180 @default.
• W39609980 hasConcept C2911091166 @default.
• W39609980 hasConcept C54355233 @default.
• W39609980 hasConcept C55493867 @default.
• W39609980 hasConcept C71924100 @default.
• W39609980 hasConcept C86803240 @default.
• W39609980 hasConceptScore W39609980C109159458 @default.
• W39609980 hasConceptScore W39609980C126322002 @default.
• W39609980 hasConceptScore W39609980C137061746 @default.
• W39609980 hasConceptScore W39609980C142724271 @default.
• W39609980 hasConceptScore W39609980C202751555 @default.
• W39609980 hasConceptScore W39609980C203014093 @default.
• W39609980 hasConceptScore W39609980C2777761686 @default.
• W39609980 hasConceptScore W39609980C2778461978 @default.
• W39609980 hasConceptScore W39609980C2780007613 @default.
• W39609980 hasConceptScore W39609980C28328180 @default.
• W39609980 hasConceptScore W39609980C2911091166 @default.
• W39609980 hasConceptScore W39609980C54355233 @default.
• W39609980 hasConceptScore W39609980C55493867 @default.
• W39609980 hasConceptScore W39609980C71924100 @default.
• W39609980 hasConceptScore W39609980C86803240 @default.
• W39609980 hasIssue "11" @default.
• W39609980 hasLocation W396099801 @default.
• W39609980 hasOpenAccess W39609980 @default.
• W39609980 hasPrimaryLocation W396099801 @default.
• W39609980 hasRelatedWork W1967018160 @default.
• W39609980 hasRelatedWork W1974500257 @default.
• W39609980 hasRelatedWork W2353278676 @default.
• W39609980 hasRelatedWork W2368356565 @default.
• W39609980 hasRelatedWork W2376145883 @default.
• W39609980 hasRelatedWork W2378664484 @default.
• W39609980 hasRelatedWork W2391166179 @default.
• W39609980 hasRelatedWork W2395603459 @default.
• W39609980 hasRelatedWork W2412418003 @default.
• W39609980 hasRelatedWork W2438891372 @default.
• W39609980 hasVolume "14" @default.
• W39609980 isParatext "false" @default.
• W39609980 isRetracted "false" @default.
• W39609980 magId "39609980" @default.
• W39609980 workType "article" @default.