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• W396925535 endingPage "e0125889" @default.
• W396925535 startingPage "e0125889" @default.
• W396925535 abstract "The mammalian intestine harbors a complex microbial ecosystem that influences many aspects of host physiology. Exposure to specific microbes early in development affects host metabolism, immune function, and behavior across the lifespan. Just as the physiology of the developing organism undergoes a period of plasticity, the developing microbial ecosystem is characterized by instability and may also be more sensitive to change. Early life thus presents a window of opportunity for manipulations that produce adaptive changes in microbial composition. Recent insights have revealed that increasing physical activity can increase the abundance of beneficial microbial species. We therefore investigated whether six weeks of wheel running initiated in the juvenile period (postnatal day 24) would produce more robust and stable changes in microbial communities versus exercise initiated in adulthood (postnatal day 70) in male F344 rats. 16S rRNA gene sequencing was used to characterize the microbial composition of juvenile versus adult runners and their sedentary counterparts across multiple time points during exercise and following exercise cessation. Alpha diversity measures revealed that the microbial communities of young runners were less even and diverse, a community structure that reflects volatility and malleability. Juvenile onset exercise altered several phyla and, notably, increased Bacteroidetes and decreased Firmicutes, a configuration associated with leanness. At the genus level of taxonomy, exercise altered more genera in juveniles than in the adults and produced patterns associated with adaptive metabolic consequences. Given the potential of these changes to contribute to a lean phenotype, we examined body composition in juvenile versus adult runners. Interestingly, exercise produced persistent increases in lean body mass in juvenile but not adult runners. Taken together, these results indicate that the impact of exercise on gut microbiota composition as well as body composition may depend on the developmental stage during which exercise is initiated." @default.
• W396925535 created "2016-06-24" @default.
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• W396925535 date "2015-05-27" @default.
• W396925535 modified "2023-10-17" @default.
• W396925535 title "Exercise Is More Effective at Altering Gut Microbial Composition and Producing Stable Changes in Lean Mass in Juvenile versus Adult Male F344 Rats" @default.
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• W396925535 cites W1529074450 @default.
• W396925535 cites W1811186957 @default.
• W396925535 cites W1905885715 @default.
• W396925535 cites W1945327512 @default.
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• W396925535 cites W1975807766 @default.
• W396925535 cites W1979055337 @default.
• W396925535 cites W1993399595 @default.
• W396925535 cites W1994684051 @default.
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• W396925535 cites W2001439699 @default.
• W396925535 cites W2003202328 @default.
• W396925535 cites W2003988648 @default.
• W396925535 cites W2004014148 @default.
• W396925535 cites W2006476121 @default.
• W396925535 cites W2007185474 @default.
• W396925535 cites W2012606594 @default.
• W396925535 cites W2012609249 @default.
• W396925535 cites W2016586816 @default.
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• W396925535 cites W2024392981 @default.
• W396925535 cites W2030091490 @default.
• W396925535 cites W2030500910 @default.
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• W396925535 cites W2045833477 @default.
• W396925535 cites W2047703946 @default.
• W396925535 cites W2052969143 @default.
• W396925535 cites W2053039168 @default.
• W396925535 cites W2058381688 @default.
• W396925535 cites W2060105624 @default.
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• W396925535 cites W2080283023 @default.
• W396925535 cites W2082565310 @default.
• W396925535 cites W2095396004 @default.
• W396925535 cites W2099664199 @default.
• W396925535 cites W2101209169 @default.
• W396925535 cites W2104890139 @default.
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• W396925535 doi "https://doi.org/10.1371/journal.pone.0125889" @default.
• W396925535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4446322" @default.
• W396925535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26016739" @default.
• W396925535 hasPublicationYear "2015" @default.
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