Matches in SemOpenAlex for { <https://semopenalex.org/work/W39696077> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W39696077 endingPage "33" @default.
- W39696077 startingPage "27" @default.
- W39696077 abstract "Neutralization of the negative charges of heparin by polycations in the fluid phase suppressed the inhibitory effect of heparin on the generation of the C3b-dependent amplification convertase of complement C3b,Bb. Polymeric polycations alone, whether natural or synthetic, prevented formation of the cell-bound amplification convertase and of the fluid-phase interaction of C3b, B and D, in a dose-related fashion in the concentration range of 1 to 2 X 10(-8)M for poly-L-lysine (PLL) 50,000. The inhibitory effect of PLL on formation of the cell-bound convertase was independent of the presence of P. Percent inhibition of C3b,Bb,P and C3b,B,P formation was constant when the convertases were formed with a fixed concentration of PLL and increasing amounts of B; PLL was more effective in preventing convertase formation on cells bearing low numbers of C3b and developed with high doses of B. The decay of the preformed P stabilized convertase was not altered by PLL whether in the presence or absence of H. Thus, polycations in the fluid phase specifically inhibit formation of the amplification C3 convertase by preventing the association between C3b and B, most likely by acting on C3b. The low-affinity interaction between C3b and B is a privileged site for natural or pharmacological modulation of complement by polyelectrolytes." @default.
- W39696077 created "2016-06-24" @default.
- W39696077 creator A5075643818 @default.
- W39696077 creator A5089629404 @default.
- W39696077 date "1983-09-01" @default.
- W39696077 modified "2023-10-18" @default.
- W39696077 title "Modulation of the formation of the human amplification C3 convertase of complement by polycations." @default.
- W39696077 cites W124424030 @default.
- W39696077 cites W1538060285 @default.
- W39696077 cites W1559536687 @default.
- W39696077 cites W1574064839 @default.
- W39696077 cites W1574312885 @default.
- W39696077 cites W1608274595 @default.
- W39696077 cites W1650628500 @default.
- W39696077 cites W1901945850 @default.
- W39696077 cites W2006623568 @default.
- W39696077 cites W2014513484 @default.
- W39696077 cites W2043403577 @default.
- W39696077 cites W2044864133 @default.
- W39696077 cites W2094275695 @default.
- W39696077 cites W2118192610 @default.
- W39696077 cites W2123919258 @default.
- W39696077 cites W2148075784 @default.
- W39696077 cites W2415141259 @default.
- W39696077 cites W2415694759 @default.
- W39696077 cites W268839726 @default.
- W39696077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1454227" @default.
- W39696077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6554235" @default.
- W39696077 hasPublicationYear "1983" @default.
- W39696077 type Work @default.
- W39696077 sameAs 39696077 @default.
- W39696077 citedByCount "3" @default.
- W39696077 countsByYear W396960772013 @default.
- W39696077 crossrefType "journal-article" @default.
- W39696077 hasAuthorship W39696077A5075643818 @default.
- W39696077 hasAuthorship W39696077A5089629404 @default.
- W39696077 hasConcept C111684460 @default.
- W39696077 hasConcept C12554922 @default.
- W39696077 hasConcept C134018914 @default.
- W39696077 hasConcept C159654299 @default.
- W39696077 hasConcept C17077164 @default.
- W39696077 hasConcept C182629451 @default.
- W39696077 hasConcept C185592680 @default.
- W39696077 hasConcept C189446657 @default.
- W39696077 hasConcept C203014093 @default.
- W39696077 hasConcept C2777557582 @default.
- W39696077 hasConcept C55493867 @default.
- W39696077 hasConcept C86803240 @default.
- W39696077 hasConcept C92731135 @default.
- W39696077 hasConcept C9478725 @default.
- W39696077 hasConceptScore W39696077C111684460 @default.
- W39696077 hasConceptScore W39696077C12554922 @default.
- W39696077 hasConceptScore W39696077C134018914 @default.
- W39696077 hasConceptScore W39696077C159654299 @default.
- W39696077 hasConceptScore W39696077C17077164 @default.
- W39696077 hasConceptScore W39696077C182629451 @default.
- W39696077 hasConceptScore W39696077C185592680 @default.
- W39696077 hasConceptScore W39696077C189446657 @default.
- W39696077 hasConceptScore W39696077C203014093 @default.
- W39696077 hasConceptScore W39696077C2777557582 @default.
- W39696077 hasConceptScore W39696077C55493867 @default.
- W39696077 hasConceptScore W39696077C86803240 @default.
- W39696077 hasConceptScore W39696077C92731135 @default.
- W39696077 hasConceptScore W39696077C9478725 @default.
- W39696077 hasIssue "1" @default.
- W39696077 hasLocation W396960771 @default.
- W39696077 hasOpenAccess W39696077 @default.
- W39696077 hasPrimaryLocation W396960771 @default.
- W39696077 hasRelatedWork W1584223221 @default.
- W39696077 hasRelatedWork W1818748811 @default.
- W39696077 hasRelatedWork W1963519109 @default.
- W39696077 hasRelatedWork W1977751215 @default.
- W39696077 hasRelatedWork W2013771339 @default.
- W39696077 hasRelatedWork W2026695565 @default.
- W39696077 hasRelatedWork W205246173 @default.
- W39696077 hasRelatedWork W2124841845 @default.
- W39696077 hasRelatedWork W2125342730 @default.
- W39696077 hasRelatedWork W2127676844 @default.
- W39696077 hasVolume "50" @default.
- W39696077 isParatext "false" @default.
- W39696077 isRetracted "false" @default.
- W39696077 magId "39696077" @default.
- W39696077 workType "article" @default.