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- W39719438 abstract "Reasons are sought for early and sustained immunodeficiency in benzo(a)pyrene (BP) exposed progeny. Quantitative assay of lymphoid tissue at 15-19 days gestation and 0-5 postnatal (PN) days showed; a striking depletion of thymic cell numbers (CN) at day 19 and PN, normal CN in fetal liver (FL) and spleen, but depression in PN spleen. Depleted THETA/sup +/ and Ly 1/sup +/ cells reflected subnormal thymic CN, while reduced amounts of Ly 2/sup +/ cells did not initiate until after birth. Spleens revealed: a) reductions in THETA/sup +/ and Ly 1/sup +/ cells at gestation, b) enhanced THETA/sup +/ cells PN and c) elevated Ly 2/sup +/ pre- and postnatally. In FL, THETA/sup +/ cells decreased, Ly 1/sup +/ did not change; in contrast, Ly 2/sup +/ were markedly elevated. The thymic Ly 1/Ly 2 ratio was > 1, while it was < 1 for spleen and FL indicating increased Ly 1/sup -/2/sup +/ cells. These data suggest disruptions in T cell ontogenesis. In preliminary experiments analysis of T cell function shows FL cells from BP-exposed progeny either as deficient in supporting in vitro proliferation of syngeneic normal spleen cells, or to induce a 3-fold inhibition of the one-way mixed lymphocyte more » response. Further studies should reveal: a) evidence for T suppressors (by the elevated Ly 2/sup +/ cells.); b) other suppressor action, if any; and c) capabilities of Ly 1/sup +/ cells. The data should help explain the deficiency of progeny in combatting syngeneic tumor growth after sc or iv transfers. « less" @default.
- W39719438 created "2016-06-24" @default.
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- W39719438 date "1986-03-01" @default.
- W39719438 modified "2023-09-27" @default.
- W39719438 title "Further studies on progeny T lymphocytes after in utero insult by benzo(a)pyrene" @default.
- W39719438 hasPublicationYear "1986" @default.
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