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- W3975443 endingPage "44" @default.
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- W3975443 abstract "Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a metabolic network of interdependent biosynthetic pathways that is compartmentalized in the cytoplasm, mitochondria, and nucleus. One‐carbon metabolism in the cytoplasm is required for the synthesis of purines and thymidylate and the remethylation of homocysteine to methionine. One‐carbon metabolism in the mitochondria is required for the synthesis of formylated methionyl‐tRNA; the catabolism of choline, purines, and histidine; and the interconversion of serine and glycine. Mitochondria are also the primary source of one‐carbon units for cytoplasmic metabolism. Increasing evidence indicates that folate‐dependent de novo thymidylate biosynthesis occurs in the nucleus of certain cell types. Disruption of folate‐mediated one‐carbon metabolism is associated with many pathologies and developmental anomalies, yet the biochemical mechanisms and causal metabolic pathways responsible for the initiation and/or progression of folate‐associated pathologies have yet to be established. This chapter focuses on our current understanding of mammalian folate‐mediated one‐carbon metabolism, its cellular compartmentation, and knowledge gaps that limit our understanding of one‐carbon metabolism and its regulation." @default.
- W3975443 created "2016-06-24" @default.
- W3975443 creator A5027619713 @default.
- W3975443 creator A5075084148 @default.
- W3975443 date "2008-01-01" @default.
- W3975443 modified "2023-10-18" @default.
- W3975443 title "Chapter 1 Folate‐Mediated One‐Carbon Metabolism" @default.
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