Matches in SemOpenAlex for { <https://semopenalex.org/work/W39774284> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W39774284 endingPage "H876" @default.
- W39774284 startingPage "H869" @default.
- W39774284 abstract "A cardiodepressant factor (CDF) was isolated (salt free) from the plasma of dogs after hypovolemic-traumatic shock by column chromatography. CDF was found to exert a concentration-dependent negative inotropic effect in guinea pig papillary muscle; it reduced the amplitude of cell wall motion, the contraction and relaxation velocity, and the frequency of spontaneously beating rat cardiomyocytes in culture, effects that were rapidly reversible upon washout. By means of electrophysiological methods (whole cell recording with patch electrodes and voltage clamp) we tested the effect of CDF on adult guinea pig cardiomyocytes: application of CDF initially decreased the plateau by 7 mV (150 ms after peak of action potential) and reduced the action potential duration by 93 ms (76% of control action potential duration) at 50% and 88 ms (79%) at 90% of repolarization. The plateau was further reduced by 13 mV and the action potential duration was prolonged by 25 ms (106%) at 50% and was prolonged drastically by 156 ms (137%) at 90% of repolarization compared with control. Voltage-clamp experiments have shown that the most prominent effect of CDF is a strong reduction of ICa accompanied by inhibition of IK and subsequent repolarization. Similar results have been obtained with neonatal rat cardiomyocytes. Blockage of the calcium inward current can explain the negative inotropic and chronotropic effect of CDF in cardiomyocytes." @default.
- W39774284 created "2016-06-24" @default.
- W39774284 creator A5010235945 @default.
- W39774284 creator A5024928342 @default.
- W39774284 creator A5030007226 @default.
- W39774284 creator A5036186602 @default.
- W39774284 creator A5088751610 @default.
- W39774284 date "1991-03-01" @default.
- W39774284 modified "2023-10-16" @default.
- W39774284 title "A cardiodepressant factor isolated from blood blocks Ca2+ current in cardiomyocytes" @default.
- W39774284 doi "https://doi.org/10.1152/ajpheart.1991.260.3.h869" @default.
- W39774284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2000981" @default.
- W39774284 hasPublicationYear "1991" @default.
- W39774284 type Work @default.
- W39774284 sameAs 39774284 @default.
- W39774284 citedByCount "17" @default.
- W39774284 countsByYear W397742842016 @default.
- W39774284 crossrefType "journal-article" @default.
- W39774284 hasAuthorship W39774284A5010235945 @default.
- W39774284 hasAuthorship W39774284A5024928342 @default.
- W39774284 hasAuthorship W39774284A5030007226 @default.
- W39774284 hasAuthorship W39774284A5036186602 @default.
- W39774284 hasAuthorship W39774284A5088751610 @default.
- W39774284 hasConcept C126322002 @default.
- W39774284 hasConcept C134018914 @default.
- W39774284 hasConcept C146403970 @default.
- W39774284 hasConcept C147944092 @default.
- W39774284 hasConcept C155710745 @default.
- W39774284 hasConcept C163415756 @default.
- W39774284 hasConcept C185263204 @default.
- W39774284 hasConcept C185592680 @default.
- W39774284 hasConcept C2778815084 @default.
- W39774284 hasConcept C42219234 @default.
- W39774284 hasConcept C71924100 @default.
- W39774284 hasConceptScore W39774284C126322002 @default.
- W39774284 hasConceptScore W39774284C134018914 @default.
- W39774284 hasConceptScore W39774284C146403970 @default.
- W39774284 hasConceptScore W39774284C147944092 @default.
- W39774284 hasConceptScore W39774284C155710745 @default.
- W39774284 hasConceptScore W39774284C163415756 @default.
- W39774284 hasConceptScore W39774284C185263204 @default.
- W39774284 hasConceptScore W39774284C185592680 @default.
- W39774284 hasConceptScore W39774284C2778815084 @default.
- W39774284 hasConceptScore W39774284C42219234 @default.
- W39774284 hasConceptScore W39774284C71924100 @default.
- W39774284 hasIssue "3" @default.
- W39774284 hasLocation W397742841 @default.
- W39774284 hasLocation W397742842 @default.
- W39774284 hasOpenAccess W39774284 @default.
- W39774284 hasPrimaryLocation W397742841 @default.
- W39774284 hasRelatedWork W2035013442 @default.
- W39774284 hasRelatedWork W2041168023 @default.
- W39774284 hasRelatedWork W2071879323 @default.
- W39774284 hasRelatedWork W2079398847 @default.
- W39774284 hasRelatedWork W2161927534 @default.
- W39774284 hasRelatedWork W2385556158 @default.
- W39774284 hasRelatedWork W2397284895 @default.
- W39774284 hasRelatedWork W2410080927 @default.
- W39774284 hasRelatedWork W3145762183 @default.
- W39774284 hasRelatedWork W39774284 @default.
- W39774284 hasVolume "260" @default.
- W39774284 isParatext "false" @default.
- W39774284 isRetracted "false" @default.
- W39774284 magId "39774284" @default.
- W39774284 workType "article" @default.