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- W398433312 abstract "Aim. The aim of this study was an analysis of published data in order to develop evidencebased clinical recommendations on chemotherapy of newly diagnosed pulmonary tuberculosis with high primary and secondary multidrug resistance. Methods. Metaanalysis and systematic review was carried out of all published randomized clinical trials on this topic. Results. Several experimental, bacteriological and clinical trials, which had performed in 1998–2003, showed a high efficacy of fluoroquinolones in patients with newly diagnosed pulmonary tuberculosis; a new effective chemotherapeutic regimen for regions with high rate of multidrug resistant tuberculosis was developed and could be administered before results of drug resistance tests are obtained. This regimen consisted of of isoniazid, rifampicin, pyrazynamide, etambutol, fluoroquinolone and kanamycin or amikacin; it was welltolerated and did not increase a rate of antibacteri al resistance of Mycobacterium tuberculosis. Conclusion . Given primary (5–10 %) and secondary (15–30 %) multidrug resistance of Mycobacterium tuberculosis in Russian Federation, the most effective chemotherapeutic regimen for patients with pulmonary tuberculosis is the combination of isoniazid, rifampicin, pyrazynamide, etam butol, fluoroquinolone and kanamycin or amikacin. A proven microbiological method for individual control of drug sensitivity of M.tuberculosis and response to chemotherapy is culturing of sputum or another biomaterial on solid or liquid media using the BACTEC MGIT equipment." @default.
- W398433312 created "2016-06-24" @default.
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- W398433312 date "2014-01-01" @default.
- W398433312 modified "2023-09-25" @default.
- W398433312 title "On contradictions in clinical guidelines on chemotherapy of patients with pulmonary tuberculosis in Russian Federation according to evidence!based medicine: meta!analysis and systematic review" @default.
- W398433312 cites W2020360659 @default.
- W398433312 doi "https://doi.org/10.18093/0869-0189-2014-0-4-80-90" @default.
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