Matches in SemOpenAlex for { <https://semopenalex.org/work/W39917526> ?p ?o ?g. }
- W39917526 endingPage "24" @default.
- W39917526 startingPage "11" @default.
- W39917526 abstract "The effects of glucocorticoid excess on regulation of insulin receptors were investigated in dexamethasone-treated rats. Glucocorticoid excess was produced by administration of dexamethasone (0.5 mg/100 g b.w.) 30 min, 4, 12, 18, 24, 42 or 70 h before experiments. This treatment caused time-dependent changes of glucose and insulin concentration in blood, as well as in amounts of specific insulin binding and insulin receptors of liver cells and erythrocytes. The time intervals in which dexamethasone produced the increase in insulin concentration were accompanied with decrease in insulin binding to receptors in membranes of liver cells, while significant changes in insulin binding to receptors of erythrocytes were not observed under the same experimental conditions. The effect is maximal 18 and 42 h after dexamethasone treatment that increase insulin blood level by about 85% and 60%, respectively. Receptor analysis revealed that changes in specific binding of insulin could be due to significant changes in amount of binding sites on cell surface rather than to mild alteration in receptor affinity. These findings suggest that besides the changes in insulin level, the alterations in insulin receptor number and affinity may play a major role in the states of altered insulin sensitivity which accompany glucocorticoid excess." @default.
- W39917526 created "2016-06-24" @default.
- W39917526 creator A5008699781 @default.
- W39917526 creator A5011991253 @default.
- W39917526 creator A5033732177 @default.
- W39917526 creator A5037949308 @default.
- W39917526 creator A5054122962 @default.
- W39917526 creator A5072077826 @default.
- W39917526 date "2006-03-01" @default.
- W39917526 modified "2023-09-25" @default.
- W39917526 title "Time dependent effects of dexamethasone on serum insulin level and insulin receptors in rat liver and erythrocytes." @default.
- W39917526 cites W1542005894 @default.
- W39917526 cites W1568178573 @default.
- W39917526 cites W1600851217 @default.
- W39917526 cites W1775749144 @default.
- W39917526 cites W1983649348 @default.
- W39917526 cites W1985700874 @default.
- W39917526 cites W1994950403 @default.
- W39917526 cites W2013826519 @default.
- W39917526 cites W2025377144 @default.
- W39917526 cites W2039201496 @default.
- W39917526 cites W2042443117 @default.
- W39917526 cites W2043813981 @default.
- W39917526 cites W2045160424 @default.
- W39917526 cites W2052137543 @default.
- W39917526 cites W2070892348 @default.
- W39917526 cites W2074598791 @default.
- W39917526 cites W2076834841 @default.
- W39917526 cites W2087742925 @default.
- W39917526 cites W2109330965 @default.
- W39917526 cites W2124647455 @default.
- W39917526 cites W2135491929 @default.
- W39917526 cites W2152199891 @default.
- W39917526 cites W2153713229 @default.
- W39917526 cites W2165906470 @default.
- W39917526 cites W2171297445 @default.
- W39917526 cites W2277683041 @default.
- W39917526 cites W2323043064 @default.
- W39917526 cites W2415359952 @default.
- W39917526 cites W44040572 @default.
- W39917526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16714772" @default.
- W39917526 hasPublicationYear "2006" @default.
- W39917526 type Work @default.
- W39917526 sameAs 39917526 @default.
- W39917526 citedByCount "3" @default.
- W39917526 countsByYear W399175262013 @default.
- W39917526 crossrefType "journal-article" @default.
- W39917526 hasAuthorship W39917526A5008699781 @default.
- W39917526 hasAuthorship W39917526A5011991253 @default.
- W39917526 hasAuthorship W39917526A5033732177 @default.
- W39917526 hasAuthorship W39917526A5037949308 @default.
- W39917526 hasAuthorship W39917526A5054122962 @default.
- W39917526 hasAuthorship W39917526A5072077826 @default.
- W39917526 hasConcept C104317684 @default.
- W39917526 hasConcept C112446052 @default.
- W39917526 hasConcept C126322002 @default.
- W39917526 hasConcept C127561419 @default.
- W39917526 hasConcept C134018914 @default.
- W39917526 hasConcept C170493617 @default.
- W39917526 hasConcept C185592680 @default.
- W39917526 hasConcept C185967709 @default.
- W39917526 hasConcept C2777391703 @default.
- W39917526 hasConcept C2779306644 @default.
- W39917526 hasConcept C2780401358 @default.
- W39917526 hasConcept C2780841215 @default.
- W39917526 hasConcept C55493867 @default.
- W39917526 hasConcept C59493245 @default.
- W39917526 hasConcept C71924100 @default.
- W39917526 hasConcept C86803240 @default.
- W39917526 hasConceptScore W39917526C104317684 @default.
- W39917526 hasConceptScore W39917526C112446052 @default.
- W39917526 hasConceptScore W39917526C126322002 @default.
- W39917526 hasConceptScore W39917526C127561419 @default.
- W39917526 hasConceptScore W39917526C134018914 @default.
- W39917526 hasConceptScore W39917526C170493617 @default.
- W39917526 hasConceptScore W39917526C185592680 @default.
- W39917526 hasConceptScore W39917526C185967709 @default.
- W39917526 hasConceptScore W39917526C2777391703 @default.
- W39917526 hasConceptScore W39917526C2779306644 @default.
- W39917526 hasConceptScore W39917526C2780401358 @default.
- W39917526 hasConceptScore W39917526C2780841215 @default.
- W39917526 hasConceptScore W39917526C55493867 @default.
- W39917526 hasConceptScore W39917526C59493245 @default.
- W39917526 hasConceptScore W39917526C71924100 @default.
- W39917526 hasConceptScore W39917526C86803240 @default.
- W39917526 hasIssue "1" @default.
- W39917526 hasLocation W399175261 @default.
- W39917526 hasOpenAccess W39917526 @default.
- W39917526 hasPrimaryLocation W399175261 @default.
- W39917526 hasRelatedWork W1603388614 @default.
- W39917526 hasRelatedWork W1965144277 @default.
- W39917526 hasRelatedWork W1983641721 @default.
- W39917526 hasRelatedWork W1992509191 @default.
- W39917526 hasRelatedWork W2000497638 @default.
- W39917526 hasRelatedWork W2001133758 @default.
- W39917526 hasRelatedWork W2022097980 @default.
- W39917526 hasRelatedWork W2031782223 @default.
- W39917526 hasRelatedWork W2037898560 @default.