Matches in SemOpenAlex for { <https://semopenalex.org/work/W400893536> ?p ?o ?g. }
- W400893536 endingPage "90" @default.
- W400893536 startingPage "75" @default.
- W400893536 abstract "The chapter focuses on the switching and mating processes of Candida species. Hull and Johnson found orthologs of three Saccharomyces cerevisiae mating-type genes in the Candida albicans mating type-like (MTL) locus. Although the scheme for mating and the regulation of the response to the mating pheromones proved in subsequent studies to be in general similar to that of S. cerevisiae and hence that of the hemiascomycetes in general, the biggest surprise was the fundamental and unique role that white-opaque switching played in the mating process of C. albicans. The response of an opaque cell to pheromone produced by the opposite mating type was shown to be highly similar to that of S. cerevisiae, including the components of the major regulatory pathway that transduces the pheromone signal. The spontaneous transition between the white and opaque phenotypes by a selected group of strains had been shown to affect a number of phenotypic and virulence traits before the discovery by Miller and Johnson that it was an essential step in the mating process. The sensitivity of the opaque phenotype to high temperature caused a conundrum regarding the relationship of host and mating. The host signals that have been identified stimulate the rate of white-to-opaque switching, but switching occurs spontaneously and in both directions. Gradients of pheromone would be extremely prone to mechanical disruption and dissipation by diffusion if in a purely liquid environment. A biofilm would provide a protective environment against disruption, and a porous matrix would reduce diffusion." @default.
- W400893536 created "2016-06-24" @default.
- W400893536 creator A5003935045 @default.
- W400893536 date "2014-04-09" @default.
- W400893536 modified "2023-09-25" @default.
- W400893536 title "Switching and Mating" @default.
- W400893536 cites W1509452146 @default.
- W400893536 cites W1537995961 @default.
- W400893536 cites W1861584374 @default.
- W400893536 cites W1881223219 @default.
- W400893536 cites W1888823860 @default.
- W400893536 cites W1893930770 @default.
- W400893536 cites W1929325285 @default.
- W400893536 cites W1934336707 @default.
- W400893536 cites W1937936144 @default.
- W400893536 cites W1937941011 @default.
- W400893536 cites W1942332747 @default.
- W400893536 cites W1966071778 @default.
- W400893536 cites W1968109336 @default.
- W400893536 cites W1976281822 @default.
- W400893536 cites W1983081734 @default.
- W400893536 cites W1983183777 @default.
- W400893536 cites W1994372181 @default.
- W400893536 cites W1996489389 @default.
- W400893536 cites W1999340863 @default.
- W400893536 cites W1999950146 @default.
- W400893536 cites W2004771191 @default.
- W400893536 cites W2006273398 @default.
- W400893536 cites W2009927771 @default.
- W400893536 cites W2019775678 @default.
- W400893536 cites W2020749481 @default.
- W400893536 cites W2020949713 @default.
- W400893536 cites W2021432006 @default.
- W400893536 cites W2035797493 @default.
- W400893536 cites W2036699947 @default.
- W400893536 cites W2038548564 @default.
- W400893536 cites W2038790269 @default.
- W400893536 cites W2039120212 @default.
- W400893536 cites W2044192693 @default.
- W400893536 cites W2045825275 @default.
- W400893536 cites W2048411015 @default.
- W400893536 cites W2049505636 @default.
- W400893536 cites W2049978018 @default.
- W400893536 cites W2056550647 @default.
- W400893536 cites W2058216045 @default.
- W400893536 cites W2058346978 @default.
- W400893536 cites W2059398061 @default.
- W400893536 cites W2060322845 @default.
- W400893536 cites W2062744432 @default.
- W400893536 cites W2064795801 @default.
- W400893536 cites W2066955442 @default.
- W400893536 cites W2073168110 @default.
- W400893536 cites W2084021973 @default.
- W400893536 cites W2084426314 @default.
- W400893536 cites W2085373613 @default.
- W400893536 cites W2085762947 @default.
- W400893536 cites W2090166478 @default.
- W400893536 cites W2090654939 @default.
- W400893536 cites W2091049152 @default.
- W400893536 cites W2092296116 @default.
- W400893536 cites W2092564946 @default.
- W400893536 cites W2093492036 @default.
- W400893536 cites W2094691111 @default.
- W400893536 cites W2096208713 @default.
- W400893536 cites W2099282704 @default.
- W400893536 cites W2099618317 @default.
- W400893536 cites W2100721452 @default.
- W400893536 cites W2102387530 @default.
- W400893536 cites W2104252198 @default.
- W400893536 cites W2105728986 @default.
- W400893536 cites W2106087641 @default.
- W400893536 cites W2108973402 @default.
- W400893536 cites W2109540663 @default.
- W400893536 cites W2109809902 @default.
- W400893536 cites W2112155746 @default.
- W400893536 cites W2116700312 @default.
- W400893536 cites W2118759693 @default.
- W400893536 cites W2120191560 @default.
- W400893536 cites W2120232022 @default.
- W400893536 cites W2122028399 @default.
- W400893536 cites W2125113143 @default.
- W400893536 cites W2126966227 @default.
- W400893536 cites W2127988357 @default.
- W400893536 cites W2128849746 @default.
- W400893536 cites W2128941915 @default.
- W400893536 cites W2130049215 @default.
- W400893536 cites W2132385062 @default.
- W400893536 cites W2133083377 @default.
- W400893536 cites W2133572247 @default.
- W400893536 cites W2133725114 @default.
- W400893536 cites W2137740696 @default.
- W400893536 cites W2137789076 @default.
- W400893536 cites W2140592743 @default.
- W400893536 cites W2141048809 @default.
- W400893536 cites W2141595874 @default.
- W400893536 cites W2141987796 @default.
- W400893536 cites W2144578112 @default.
- W400893536 cites W2144842227 @default.