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- W401562060 abstract "Classic immunologic theory suggests that antigens are supplied to the immune system by the outside world (such as infectious agents), and by the self, where they originate from proteins or other molecules that are plentiful in various organ systems (such as thyroglobulin, nucleosome, or myosin). Recent information suggests that antibody molecules themselves can serve as a source of peptides that activate T lymphocytes, which can then serve as helpers or regulators of autoantibody production. Furthermore, enhanced recognition of these immunoglobulin (Ig)-derived peptides may be a feature of autoimmunity. For example, spontaneous recognition of Ig-derived peptides is an early feature of abnormal immune responses in the NZB/NZW F1 female (BW) mouse, a strain genetically programmed to develop IgG antibodies to double-stranded DNA (dsDNA) and lethal lupus-like immune glomerulonephritis with age. Similar responsiveness probably occurs in patients with systemic lupus erythematosus (SLE). This chapter reviews the evidence that this process occurs, that it is important in the poorly regulated, sustained pathogenic autoantibody production characteristic of murine and human SLE, and that targeting it for suppression has the potential of providing a novel therapeutic approach to this disease." @default.
- W401562060 created "2016-06-24" @default.
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- W401562060 date "1999-01-01" @default.
- W401562060 modified "2023-09-23" @default.
- W401562060 title "Autoantibodies as a Source of Peptides That Regulate Autoantibody Production" @default.
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- W401562060 doi "https://doi.org/10.1007/978-1-59259-703-1_23" @default.
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