Matches in SemOpenAlex for { <https://semopenalex.org/work/W40186105> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W40186105 abstract "One of the most abundant aldehydic components of ox-LDL is 4-Hydroxynonenal(HNE) which exerts various effects on intracellular and extracellular signalingcascades. HNE was demonstrated to be able to induce apoptosis and ROSformation in a dose dependent manner in a number of studies. Several signalingpathways have been shown to be modulated by HNE, including MAP kinases,PKC isoforms, cell cycle regulators, receptor tyrosine kinases and caspases. Wehave studied MAP kinase and caspase activation pathways in 3T3 fibroblasts inorder to shed light on the mechanisms that HNE induces apoptosis.HNE induced early activation of JNK and p38 proteins but downregulated thebasal activity of ERK 1/2. We have shown that HNE induced caspase-9 and 3activation and release of cytochrome c from mitochondria. Overexpression studiesand utilization of specific kinase inhibitors indicated that HNE induced apoptosis through activation of JNK and c-Jun/AP-1 protein. We also demonstrated that resveratrol, a widely distributed flavone, may protect against HNE-inducedapoptosis through modulation of JNK activation upstream of mitochondrialapoptotic pathway. Activation of AP-1 along with increased c-Jun and phospho-c-Jun levels could be inhibited by pretreatment of cells with resveratrol.Further investigations about the cellular mechanism of apoptotic response to HNEare in progress by a specific focus on the involvement of pro and anti-apoptoticmembers of Bcl-2 protein family in our laboratory." @default.
- W40186105 created "2016-06-24" @default.
- W40186105 creator A5000555372 @default.
- W40186105 creator A5001623749 @default.
- W40186105 creator A5028118284 @default.
- W40186105 creator A5089326565 @default.
- W40186105 date "2007-01-01" @default.
- W40186105 modified "2023-09-24" @default.
- W40186105 title "HNE (4-hydroxynonenal ) induces apoptosis via mitochondrial pathway with the involvement of Bcl-2 family members" @default.
- W40186105 hasPublicationYear "2007" @default.
- W40186105 type Work @default.
- W40186105 sameAs 40186105 @default.
- W40186105 citedByCount "0" @default.
- W40186105 crossrefType "journal-article" @default.
- W40186105 hasAuthorship W40186105A5000555372 @default.
- W40186105 hasAuthorship W40186105A5001623749 @default.
- W40186105 hasAuthorship W40186105A5028118284 @default.
- W40186105 hasAuthorship W40186105A5089326565 @default.
- W40186105 hasConcept C184235292 @default.
- W40186105 hasConcept C185592680 @default.
- W40186105 hasConcept C190283241 @default.
- W40186105 hasConcept C2776151105 @default.
- W40186105 hasConcept C2779308327 @default.
- W40186105 hasConcept C2780829032 @default.
- W40186105 hasConcept C28859421 @default.
- W40186105 hasConcept C29311851 @default.
- W40186105 hasConcept C31573885 @default.
- W40186105 hasConcept C51551487 @default.
- W40186105 hasConcept C55493867 @default.
- W40186105 hasConcept C57074206 @default.
- W40186105 hasConcept C62478195 @default.
- W40186105 hasConcept C86803240 @default.
- W40186105 hasConcept C95444343 @default.
- W40186105 hasConcept C98424977 @default.
- W40186105 hasConceptScore W40186105C184235292 @default.
- W40186105 hasConceptScore W40186105C185592680 @default.
- W40186105 hasConceptScore W40186105C190283241 @default.
- W40186105 hasConceptScore W40186105C2776151105 @default.
- W40186105 hasConceptScore W40186105C2779308327 @default.
- W40186105 hasConceptScore W40186105C2780829032 @default.
- W40186105 hasConceptScore W40186105C28859421 @default.
- W40186105 hasConceptScore W40186105C29311851 @default.
- W40186105 hasConceptScore W40186105C31573885 @default.
- W40186105 hasConceptScore W40186105C51551487 @default.
- W40186105 hasConceptScore W40186105C55493867 @default.
- W40186105 hasConceptScore W40186105C57074206 @default.
- W40186105 hasConceptScore W40186105C62478195 @default.
- W40186105 hasConceptScore W40186105C86803240 @default.
- W40186105 hasConceptScore W40186105C95444343 @default.
- W40186105 hasConceptScore W40186105C98424977 @default.
- W40186105 hasLocation W401861051 @default.
- W40186105 hasOpenAccess W40186105 @default.
- W40186105 hasPrimaryLocation W401861051 @default.
- W40186105 hasRelatedWork W143415333 @default.
- W40186105 hasRelatedWork W172311616 @default.
- W40186105 hasRelatedWork W2040919051 @default.
- W40186105 hasRelatedWork W2045067023 @default.
- W40186105 hasRelatedWork W2051614284 @default.
- W40186105 hasRelatedWork W2065943100 @default.
- W40186105 hasRelatedWork W2072232908 @default.
- W40186105 hasRelatedWork W2076381778 @default.
- W40186105 hasRelatedWork W2081716875 @default.
- W40186105 hasRelatedWork W2083262462 @default.
- W40186105 hasRelatedWork W2086127940 @default.
- W40186105 hasRelatedWork W2089003420 @default.
- W40186105 hasRelatedWork W2092532895 @default.
- W40186105 hasRelatedWork W2094331623 @default.
- W40186105 hasRelatedWork W2096980517 @default.
- W40186105 hasRelatedWork W2129739698 @default.
- W40186105 hasRelatedWork W2145365474 @default.
- W40186105 hasRelatedWork W2156302341 @default.
- W40186105 hasRelatedWork W2164151710 @default.
- W40186105 hasRelatedWork W3177448763 @default.
- W40186105 isParatext "false" @default.
- W40186105 isRetracted "false" @default.
- W40186105 magId "40186105" @default.
- W40186105 workType "article" @default.