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- W40199135 abstract "Mouse protection tests were conducted with vaccines prepared from Brucella abortus or Listeria monocytogenes by means of x rays or formaldehyde. B. abortus (Buck 19 strain) was killed by irradiation with 50-kv x rays while suspended in saline solution. The absolute sterilizing dose for 10/sup 10/ bacteria was 1.5 Mr. Vaccine prepared in this way, or by treatment with HCHO at a concentration of 0.2%, was injected with Al(OH)/sub 3/ in mice. When the mice were subsequently challenged with living bacteria, the survival rate was 43% in mice immunized with radioinactivated vaccine, 30% in those given formalized vaccine, and 0% in unvaccinated controls. Vaccines were similarly prepared and tested using L. monocytogenes, except the x-ray sterilizing dose was 1.0 Mr. With both irradiated and formalized vaccines the survival rate of challenged mice was 5%, compared with 0% in unvaccinated controls. Although the results indicate that there is little difference between the protection afforded by vaccines prepared with x rays or re HCHO, the irradiated vaccines were somewhat better tolerated by the mice than formalized vaccines. (H.H.D.)" @default.
- W40199135 created "2016-06-24" @default.
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- W40199135 date "1962-01-01" @default.
- W40199135 modified "2023-09-26" @default.
- W40199135 title "PROPHYLACTIC VACCINATION WITH VACCINES OF BACTERIA INACTIVATED BY X IRRADIATION" @default.
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