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- W40258841 abstract "The hippocampus has a peculiarly restricted extracellular space, not so much because its extracellular clefts are specially narrow, but rather because they are very little ramified (Green and Maxwell, 1961). Beatriz Vasquez and I, in 1967 (unpublished) obtained inulin space values of 7.9 ± 1.2% (n=12) for rat hippocampus, against 13.3 ± 2.1% (n=4; p below 0.0005) for the remainder of the cerebral hemisphere. Measurements of the relative surface occupied by extracellular clefts in electron micrographs of rat stratum pyramidale and radiale (Green and Maxwell, 1961) gave in our hands even smaller values, of 2.0% or less. In these layers of the hippocampus, neurones are opposed to each other for long stretches, separated only by the intercellular clefts, with no interposed glial processes (Green, 1964; Green and Maxwell, 1961), and the situation is clearly like an extreme case of those theoretically studied by Lebovitz (1970) in which neuronal activity causes long-lasting (K+)o accumulations." @default.
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- W40258841 date "1974-01-01" @default.
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- W40258841 title "Regulation of Hippocampal Information Processing By K+ Release and (K+)o Accumulation: Possible Role in Learning" @default.
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- W40258841 doi "https://doi.org/10.1007/978-1-4684-3066-0_9" @default.
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