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- W40282385 abstract "This chapter focuses on human chorionic gonadotropin (HCG), a glycoprotein hormone produced by the placenta that appears in significant quantities in the urine during the first trimester of pregnancy. The mean level of urinary HCG produced during the first trimester is 30,000–50,000 IU in 24 hours, equivalent to a maximum of approximately 3 mg of hormone. The high proline content is of particular interest because proline is an uncommon amino acid in most proteins and only collagen appears to have a higher content than HCG. Equilibrium sedimentation studies of reduced, alkylated HCG in the ultracentrifuge indicated that the molecular weight value had fallen to approximately one-half of that of the native hormone. Interchange of the HCG subunits with other molecules might lead to the appearance of different substances possessing other biological activities. Another possibility is that the pooled urinary material from which the HCG was purified was contaminated with a significant quantity of postmenopausal urine." @default.
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- W40282385 date "1971-01-01" @default.
- W40282385 modified "2023-10-06" @default.
- W40282385 title "Studies of Human Chorionic Gonadotropin" @default.
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- W40282385 doi "https://doi.org/10.1016/b978-0-12-571127-2.50028-6" @default.
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