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- W40371475 abstract "Modification of therapeutic proteins and peptides by polyethylene glycol conjugation is a well known method to improve the pharmacological properties of such drugs. Here we describe an alternative way of PEGylation from classic chemical methods, taking advantage of enzymes able to specifically modify some amino acid side chains, in particular glycosyltransferases and transglutaminases. A few examples are here described, in particular granulocyte-colony stimulating factor, which has been successfully PEGylated by enzymatic methods leading to a new long-lasting compound presently under evaluation in clinical studies." @default.
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- W40371475 date "2009-01-01" @default.
- W40371475 modified "2023-10-08" @default.
- W40371475 title "Enzymatic techniques for PEGylation of biopharmaceuticals" @default.
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- W40371475 doi "https://doi.org/10.1007/978-3-7643-8679-5_5" @default.
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