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• W40377072 abstract "Abstract Isolated hepatocytes and perfused livers can furnish important data linking enzymological information obtained with homogenates and subcellular fractions to liver biotransformation in vivo. To obtain meaningful data with these systems, mode of delivery of xenobiotic substrates to intracellular enzymes must be understood. Because of the varying degrees to which non-ionic lipid-soluble xenobiotics bind to intra- and extracellular proteins, the composition of media for hepatocyte suspensions and liver perfusion is an important determinant of intracellular xenobiotic concentration and hence its metabolism. Metabolic sequestration of xenobiotics along the hepatic sinusoid produces a gradient of xenobiotic exposure across the lobule. When the transfer of xenobiotics between the hepatic circulation and hepatocytes is rapid, nearly all influent dose is absorbed by periportal hepatocytes and undergoes chromatographic translobular migration. Such translobular pattern of exposure must be defined for each xenobiotic because different regions of the hepatic lobule are metabolically unique. Recent efforts to understand the significance of intralobular heterogeneity include fractionation of the heterogeneous hepatocyte population, enzyme analysis following region-specific damage, and perfusion analyses." @default.
• W40377072 created "2016-06-24" @default.
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• W40377072 date "1983-01-01" @default.
• W40377072 modified "2023-10-03" @default.
• W40377072 title "METABOLISM STUDIES WITH LIVER HOMOGENATE, HEPATOCYTE SUSPENSION AND PERFUSED LIVER" @default.
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• W40377072 doi "https://doi.org/10.1016/b978-0-08-029224-3.50066-6" @default.
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