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- W40383676 abstract "Hyperthermia involves the use of heat to treat malignancy. There are references to the therapeutic use of heat in ancient Egypt (Edwin Smith surgical papyrus, c. 1700 BC) and Hippocrates stated that “diseases not cured by drugs are cured by surgery, conditions not cured by surgery are cured by cauterisation and conditions not cured by cauterisation should be considered incurable”. It was not, however, until the end of the nineteenth century that the scientific study of the effect of heat on malignancies was begun. The first observations were in Germany in the 1860s, but Coley (Coley 1894) in America treated patients with sarcomas by injecting a mixture of bacterial toxins and raising the body temperature to 41–42 °C for 4–6 hours. The results of this work were a demonstrable response in over half of those treated and an increase in expected survival in 20%. After this, interest in hyperthermia fell with the introduction and use of radiotherapy for treating cancers. Since the 1950s there has been an increased interest in the possible use of hyperthermia to treat cancer, and a vast amount of experimental work to investigate the mechanisms by which heat has its effect and the outcome of clinical applications (Hahn 1982)." @default.
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- W40383676 date "1990-01-01" @default.
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- W40383676 title "Interstitial Hyperthermia of the Prostate" @default.
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- W40383676 doi "https://doi.org/10.1007/978-1-4471-1783-4_7" @default.
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