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• W40428639 abstract "This chapter discusses the mechanism of action of pituitary growth hormone. Growth is intrinsically associated with protein synthesis, a process subject to regulation at many points by a variety of agents. About 20 different types of amino acids are required to be available in cellular proteins. Enough ATP and GTP need be generated in view of the fact that for formation of each peptide bond, one high-energy bond of ATP and two of GTP are consumed. The amount of proteins synthesized is related to the number of protein synthesizing units. Thus, increased protein synthesis is invariably associated with an increase in ribosomes and polysomes. As ribosomes are mostly bound to the membrane in eukaryotic cells, there is a concomitant laying down of the endoplasmic reticulum in these cells. Growth-promoting and developmental hormones can exercise direct or indirect influences on any one or more of the numerous control points in the synthesis of proteins. Administration of growth hormone induces a positive nitrogen balance. The manifold actions of pituitary growth hormone stem from the widespread, almost ubiquitous, presence of 'receptors for this hormone in many tissues of the body. In some tissues, the hormonal effect is direct whereas in others, it is indirect and is mediated by substances generated by the action of the hormone in alternate organs. This relationship may partially account for the lag period noticed in elicitation of the hormonal effects." @default.
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• W40428639 date "1975-01-01" @default.
• W40428639 modified "2023-10-14" @default.
• W40428639 title "Mechanism of Action of Pituitary Growth Hormone" @default.
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• W40428639 doi "https://doi.org/10.1016/b978-0-12-571131-9.50008-6" @default.
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