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- W40648734 abstract "Patients with de novo acute myeloid leukemias (AML) and a normal karyotype are considered to be associated with an intermediate prognosis. The aim of the study was to determine the influence of erythroid and/or megakaryocytic dysplasia (EMD) in diagnostic bone marrow smears of patients under 65 years with de novo AML and a normal karyotype on their response to therapy and prognosis. EMD was diagnosed when more than 25% erythroblasts and/or 50% megakaryocytes exhibited dysplastic features evaluated according to the FAB criteria. Twenty-three patients with AML and a normal karyotype were diagnosed between 02/1991-05/1995. Ten cases, 21–65 (median 47) years old, were categorized without EMD, eleven patients 34–63 (median 56) years old with EMD, and two patients were not evaluable for EMD. One cycle of therapy consisting of 3-4 doses of daunorubicin (DNR) 45 mg/m2/d and cytosine arabinoside (AraC) 150–200 mg/m2/12-h for 7 days induced 8 complete (CR) and 2 partial remissions in 10 cases without EMD but in 8 cases with EMD one CR, 6 non-responses and one induction death (p=0.015). However, six of seven patients with EMD reached CR with high doses of AraC 2,000 mg/m2/12-h x 10 plus 2 doses of DNR.. Median event-free survival in patients without EMD was 25.1 months and 3.5 months in cases with EMD (p=0.08). Our data have shown a probable existence of two different categories of AML with a normal karyotype distinguished by the presence of EMD. These categories seem to differ in the response to classical induction chemotherapy 3+7 and prognosis." @default.
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- W40648734 date "2001-01-01" @default.
- W40648734 modified "2023-10-16" @default.
- W40648734 title "Are there Two Main Categories of de Novo Acute Myeloid Leukemias with a Normal Karyotype?" @default.
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- W40648734 doi "https://doi.org/10.1007/978-3-642-18156-6_10" @default.
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