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- W40696078 endingPage "716" @default.
- W40696078 startingPage "701" @default.
- W40696078 abstract "This chapter summarizes the natural history of bone loss and fracture associated with kidney, heart, lung, liver, and bone marrow transplantation. It reviews the changes in calciotropic hormones and biochemical markers of bone turnover that follow various types of organ transplants. Candidates for all types of transplantation have significant risk factors for osteoporosis and many have low bone mass, prevalent fractures, or evidence of abnormal mineral metabolism before transplantation. In the majority of cases, markers of both bone formation and resorption are increased before transplantation. The exception to this is cholestatic liver disease in which bone turnover is low before transplantation. After transplantation, there is a rapid bone loss in majority of patients, and fractures also occur commonly. These complications occur with the greatest frequency during the first 6 to 12 months. Early after transplantation, when glucocorticoid doses are the highest, serum ostocalcin and bone alkaline phosphatase are suppressed and markers of resorption are elevated, biochemical evidence of uncoupled formation and resorption. However, bone formation markers recover by the middle of the first year after transplantation. The balance of the evidence in organ transplant recipients evaluated after the first 6 months favors the notion that transplantation related bone loss is a form of high turnover osteoporosis. As such, antiresorptive therapy is likely to have benefits in the prevention of bone loss and fractures after transplantation." @default.
- W40696078 created "2016-06-24" @default.
- W40696078 creator A5011350113 @default.
- W40696078 creator A5069333159 @default.
- W40696078 date "2006-01-01" @default.
- W40696078 modified "2023-09-25" @default.
- W40696078 title "Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment" @default.
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