FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W407214> ?p ?o ?g. }

• W407214 endingPage "215" @default.
• W407214 startingPage "191" @default.
• W407214 abstract "This chapter describes the immunostimulating complex, referred to as an “iscom” or ISCOMTM vaccine, as a novel structure for antigenic presentation of membrane proteins from enveloped viruses with potent immunomodulatory capability. Since this discovery, many ISCOMTM vaccines have been tested in animal models showing the induction of both humoral and cellular immune responses. ISCOMATRIXTM adjuvant is essentially the same structure as the ISCOMTM vaccine but without the incorporated antigen. Antigens can be formulated with the ISCOMATRIXTM adjuvant to produce ISCOMATRIXTM vaccines providing the same antigen presentation and immunomodulatory properties as ISCOMTM vaccines but with much broader application. Various ISCOMATRIXTM vaccines have been tested in animal models and more recently in human clinical trials. All results to date indicate that ISCOMATRIXTM vaccines are safe and well tolerated in humans with no vaccine-related serious adverse events or laboratory abnormalities. ISCOMATRIXTM vaccines are capable of inducing strong humoral responses with increases in the magnitude, speed, and longevity of the responses, as well as the capacity for antigen dose reduction when compared to other adjuvants such as aluminum. The ability of the ISCOMATRIXTM adjuvant to induce these broad immune responses is due to the fact that it is both an effective antigen delivery vehicle, which can access both the MHC I and MHC II pathways, and a potent immunomodulator of both the innate and adaptive immune systems. Overall, the properties of ISCOMATRIXTM vaccines make them viable candidates for the further development and registration of prophylactic and therapeutic human vaccines." @default.
• W407214 created "2016-06-24" @default.
• W407214 creator A5033376741 @default.
• W407214 creator A5068887019 @default.
• W407214 date "2006-01-01" @default.
• W407214 modified "2023-09-23" @default.
• W407214 title "The ISCOMATRIX™ adjuvant" @default.
• W407214 cites W1507548252 @default.
• W407214 cites W1509514214 @default.
• W407214 cites W1526119470 @default.
• W407214 cites W1567772800 @default.
• W407214 cites W1586546000 @default.
• W407214 cites W1655860314 @default.
• W407214 cites W1789487523 @default.
• W407214 cites W1831319429 @default.
• W407214 cites W1952863055 @default.
• W407214 cites W1965588035 @default.
• W407214 cites W1966111196 @default.
• W407214 cites W1967780364 @default.
• W407214 cites W1968114019 @default.
• W407214 cites W1968554125 @default.
• W407214 cites W1969605397 @default.
• W407214 cites W1970077852 @default.
• W407214 cites W1971148645 @default.
• W407214 cites W1972312879 @default.
• W407214 cites W1979391079 @default.
• W407214 cites W1979439802 @default.
• W407214 cites W1992269173 @default.
• W407214 cites W1995964595 @default.
• W407214 cites W2000694244 @default.
• W407214 cites W2000801374 @default.
• W407214 cites W2002392006 @default.
• W407214 cites W2004815678 @default.
• W407214 cites W2006104205 @default.
• W407214 cites W2006530173 @default.
• W407214 cites W2008051431 @default.
• W407214 cites W2008557355 @default.
• W407214 cites W2009238488 @default.
• W407214 cites W2012316443 @default.
• W407214 cites W2013671168 @default.
• W407214 cites W2014399113 @default.
• W407214 cites W2019210740 @default.
• W407214 cites W2024382513 @default.
• W407214 cites W2025372248 @default.
• W407214 cites W2026449033 @default.
• W407214 cites W2026494637 @default.
• W407214 cites W2028356464 @default.
• W407214 cites W2028873831 @default.
• W407214 cites W2032581743 @default.
• W407214 cites W2033905138 @default.
• W407214 cites W2039541188 @default.
• W407214 cites W2042174530 @default.
• W407214 cites W2042470561 @default.
• W407214 cites W2049672409 @default.
• W407214 cites W2051486649 @default.
• W407214 cites W2052118324 @default.
• W407214 cites W2054916084 @default.
• W407214 cites W2055171880 @default.
• W407214 cites W2057010810 @default.
• W407214 cites W2065884184 @default.
• W407214 cites W2069929345 @default.
• W407214 cites W2079439306 @default.
• W407214 cites W2083537825 @default.
• W407214 cites W2083606551 @default.
• W407214 cites W2083876711 @default.
• W407214 cites W2084494037 @default.
• W407214 cites W2087580809 @default.
• W407214 cites W2094868581 @default.
• W407214 cites W2098765233 @default.
• W407214 cites W2103465870 @default.
• W407214 cites W2105418223 @default.
• W407214 cites W2106859466 @default.
• W407214 cites W2108473659 @default.
• W407214 cites W2108838669 @default.
• W407214 cites W2109648575 @default.
• W407214 cites W2119344429 @default.
• W407214 cites W2123134831 @default.
• W407214 cites W2133449490 @default.
• W407214 cites W2135823791 @default.
• W407214 cites W2137088550 @default.
• W407214 cites W2139605631 @default.
• W407214 cites W2150835657 @default.
• W407214 cites W2165626477 @default.
• W407214 cites W2167009516 @default.
• W407214 cites W2314426169 @default.
• W407214 cites W75058160 @default.
• W407214 doi "https://doi.org/10.1016/b978-012088403-2/50013-7" @default.
• W407214 hasPublicationYear "2006" @default.
• W407214 type Work @default.
• W407214 sameAs 407214 @default.
• W407214 citedByCount "8" @default.
• W407214 countsByYear W4072142013 @default.
• W407214 countsByYear W4072142015 @default.
• W407214 countsByYear W4072142016 @default.
• W407214 countsByYear W4072142023 @default.
• W407214 crossrefType "book-chapter" @default.
• W407214 hasAuthorship W407214A5033376741 @default.
• W407214 hasAuthorship W407214A5068887019 @default.

• next